4685-51-2

Basic information

• Product Name: 3-METHOXY-4-METHYLBENZYL CHLORIDE
• Synonyms: 3-METHOXY-4-METHYLBENZYL CHLORIDE
• CAS NO: 4685-51-2
• Molecular Formula: C₉H₁₁ClO
• Molecular Weight: 170.63604
• Mol File: 4685-51-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-METHOXY-4-METHYLBENZYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-4-METHYLBENZYL CHLORIDE(4685-51-2)
• EPA Substance Registry System: 3-METHOXY-4-METHYLBENZYL CHLORIDE(4685-51-2)

Safety Data

• Hazardous Substances Data: 4685-51-2(Hazardous Substances Data)

Usage

General Description

3-Methoxy-4-methylbenzyl chloride is a chemical compound with the molecular formula C9H11ClO. It is a clear, colorless liquid with a faint aromatic odor. 3-METHOXY-4-METHYLBENZYL CHLORIDE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized as a building block in the production of perfumes and flavoring agents. Additionally, 3-methoxy-4-methylbenzyl chloride is employed in organic synthesis to introduce the 4-methyl-3-methoxyphenyl group into various molecules. It is important to handle this compound with care, as it is corrosive and may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 4685-50-1 3-methoxy-4-methylbenzyl alcohol 
• 42981-94-2 1-(chloromethyl)-3-methoxy-2-methylbenzene 
• 7151-68-0 3-methoxy-p-toluic acid 
• 62454-72-2 4-methyl-3-sulfobenzoic acid 
• 104901-43-1 methyl 3-bromo-4-methylbenzoate 
• 3556-83-0 methyl 4-methyl-3-methoxybenzoate 
• 7697-26-9 3-bromo-4-methylbenzoic acid 

Downstream Products

• 64829-31-8 2-(3-methoxy-4-methylphenyl)acetonitrile 
• 4685-61-4 C₂₀H₁₈N₂O₂ 
• 4685-58-9 2-Hydroxy-3,6,8-trimethyl-benzocyclohepten-7-one 
• 51814-28-9 1-(3-methoxy-4-methylphenyl)-2-propanone 
• 24160-29-0 1-(3-methoxy-4-methyl-phenyl)propan-2-amine 
• 98698-18-1 2-acetylamino-2-(3-methoxy-4-methylbenzyl)malonic acid diethyl ester 
• 122334-01-4 ethyl 4-(3-methoxy-4-methylphenyl)butanoate 
• 122334-02-5 4-(3-methoxy-4-methylphenyl)butanoic acid 
• 4685-52-3 1,2-Bis-chloromethyl-4-methoxy-5-methyl-benzene 

Relevant articles and documents

Stereoselective Synthesis of the Spirocyclic γ-Lactam Core of the Ansalactams

Ansalactam A is an ansa macrolide natural product that contains a densely functionalized spiro-γ-lactam core containing three contiguous stereocenters. This unusual motif distinguishes it from other members of this family and represents a significant synthetic challenge. Herein, we report the development of a stereoselective formal [3+2] cycloaddition reaction for the construction of this key spiro-γ-lactam motif for the first time, thereby enabling access to the northern domain of ansalactam A.

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Stereoselective syntheses of (±)-komaroviquinone and (±)-faveline methyl ether through intramolecular Heck reaction

An efficient, flexible, and stereoselective convergent route for constructing the trans-10-hydroxy-1,1-dimethyloctahydrodibenzo[a,d]cyclohepten- 7-ones (5a-c) was achieved via intramolecular Heck reaction. This strategy has been successfully implemented for the syntheses of (±)-komaroviquinone (3) through (±)-coulterone dimethyl ether (5c) and (±)-faveline methyl ether (1a).