4685-51-2

Usage

General Description

3-Methoxy-4-methylbenzyl chloride is a chemical compound with the molecular formula C9H11ClO. It is a clear, colorless liquid with a faint aromatic odor. 3-METHOXY-4-METHYLBENZYL CHLORIDE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized as a building block in the production of perfumes and flavoring agents. Additionally, 3-methoxy-4-methylbenzyl chloride is employed in organic synthesis to introduce the 4-methyl-3-methoxyphenyl group into various molecules. It is important to handle 3-METHOXY-4-METHYLBENZYL CHLORIDE with care, as it is corrosive and may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 4685-50-1 3-methoxy-4-methylbenzyl alcohol 
• 42981-94-2 1-(chloromethyl)-3-methoxy-2-methylbenzene 
• 7151-68-0 3-methoxy-p-toluic acid 
• 62454-72-2 4-methyl-3-sulfobenzoic acid 
• 104901-43-1 methyl 3-bromo-4-methylbenzoate 
• 3556-83-0 methyl 4-methyl-3-methoxybenzoate 
• 7697-26-9 3-bromo-4-methylbenzoic acid 

Downstream Products

• 64829-31-8 2-(3-methoxy-4-methylphenyl)acetonitrile 
• 122334-02-5 4-(3-methoxy-4-methylphenyl)butanoic acid 
• 122334-01-4 ethyl 4-(3-methoxy-4-methylphenyl)butanoate 
• 98698-18-1 2-acetylamino-2-(3-methoxy-4-methylbenzyl)malonic acid diethyl ester 
• 24160-29-0 1-(3-methoxy-4-methyl-phenyl)propan-2-amine 
• 51814-28-9 1-(3-methoxy-4-methylphenyl)-2-propanone 
• 4685-58-9 2-Hydroxy-3,6,8-trimethyl-benzocyclohepten-7-one 
• 4685-61-4 C₂₀H₁₈N₂O₂ 
• 4685-52-3 1,2-Bis-chloromethyl-4-methoxy-5-methyl-benzene 

Relevant academic research and scientific papers

Stereoselective Synthesis of the Spirocyclic γ-Lactam Core of the Ansalactams

Ansalactam A is an ansa macrolide natural product that contains a densely functionalized spiro-γ-lactam core containing three contiguous stereocenters. This unusual motif distinguishes it from other members of this family and represents a significant synthetic challenge. Herein, we report the development of a stereoselective formal [3+2] cycloaddition reaction for the construction of this key spiro-γ-lactam motif for the first time, thereby enabling access to the northern domain of ansalactam A.

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases

The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P1 and S1P5, is described. While it has been revealed that the modulation of the S1P1 receptor is an effective way to treat autoimmune diseases such as relapsing-remitting multiple sclerosis (RRMS), it was also reported that activation of the S1P3 receptor is implicated in some undesirable effects. We carried out a structure-activity relationship (SAR) study of hit compound 6 with an amino acid moiety in the hydrophilic head region. Following identification of a lead compound with a dihydronaphthalene central core by inducing conformational constraint, optimization of the lipophilic tail region led to the discovery of 13n as a clinical candidate that exhibited >30 000-fold selectivity for S1P1 over S1P3 and was potent in a peripheral lymphocyte lowering (PLL) test in mice (ED50 = 0.029 mg/kg, 24 h after oral dosing).

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Piperazine derivatives

This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Stereoselective syntheses of (±)-komaroviquinone and (±)-faveline methyl ether through intramolecular Heck reaction

An efficient, flexible, and stereoselective convergent route for constructing the trans-10-hydroxy-1,1-dimethyloctahydrodibenzo[a,d]cyclohepten- 7-ones (5a-c) was achieved via intramolecular Heck reaction. This strategy has been successfully implemented for the syntheses of (±)-komaroviquinone (3) through (±)-coulterone dimethyl ether (5c) and (±)-faveline methyl ether (1a).

Amidine derivatives and cardiotonic compositions

Amidine derivatives of the formula STR1 wherein R1 and R2, which may be the same or different, represent each a hydrogen atom or a lower alkyl group, or R1 and R2 together with an intermediary carbon atom and/or hetero atom may form a ring; X represents STR2 (wherein R8 represents a hydrogen atom, a lower alkyl group, or --CH2 COOR9, where R9 represents a hydrogen atom or a lower alkyl group; Z represents a single bond, --CH2 --, --CH2 CH2 --, or --CH=CH--); R3 represents a hydrogen or chlorine atom, methoxy group, nitro group, or amino group; Y represents --CH2 CH2 --, --CH=CH--, --CH2 O--, or --OCH2 --; R4 represents a hydrogen atom, methoxy group, benzoyl group, nitro group, or amino group; and R5, R6 and R7, which may be the same or different, represent each a hydrogen atom, lower alkyl group, cycloalkyl group, aralkyl group, substituted alkyl group, substituted aralkyl group, or amino group, or R5 and R7 may form a ring, or salts thereof have an excellent cardiotonic activity and can be used as cardiotonics.