64829-31-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Methoxy-4-methylphenylacetonitrile is used as a key intermediate for the synthesis of various pharmaceuticals. Its ability to be converted into carboxylic acids, amines, and other nitrogen-containing compounds makes it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Methoxy-4-methylphenylacetonitrile serves as an essential intermediate for the production of various agrochemicals. Its versatility in organic synthesis allows for the creation of compounds that can be used in pest control and crop protection.
Used in Organic Synthesis:
3-Methoxy-4-methylphenylacetonitrile is used as a versatile building block in organic synthesis for the preparation of a wide range of chemical products. Its nitrile group facilitates the synthesis of carboxylic acids, amines, and other nitrogen-containing compounds, making it a valuable starting material for various chemical reactions.
Safety Precautions:
It is important to handle 3-Methoxy-4-methylphenylacetonitrile with care, as it can be harmful if ingested, inhaled, or absorbed through the skin. Appropriate safety measures should be taken when working with this chemical to ensure the well-being of individuals and the environment.

InChI:InChI=1/C10H11NO/c1-8-3-4-9(5-6-11)7-10(8)12-2/h3-4,7H,5H2,1-2H3

Upstream product

• 4685-50-1 3-methoxy-4-methylbenzyl alcohol 
• 143-33-9 sodium cyanide 
• 7151-68-0 3-methoxy-p-toluic acid 
• 586-30-1 3-hydroxy-4-methylbenzoic acid 
• 4685-51-2 4-(chloromethyl)-2-methoxy-1-methylbenzene 
• 24973-22-6 3-methoxy-4-methylbenzaldehyde 
• 57295-30-4 3-hydroxy-4-methylbenzaldehyde 

Downstream Products

• 64829-32-9 1-Cyano-1-(3-methoxy-4-methylphenyl)-aceton 
• 75097-32-4 2-bromo-5-methoxy-4-methylphenylacetic acid 
• 75156-81-9 methyl α-bromo-(2-bromo-5-methoxy-4-methylphenyl)acetate 
• 75156-82-0 methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate 
• 75156-86-4 methyl α-<3-acetoxy-4-(N-ethoxycarbonyl-N-methylamino)-pyrrolidin-2-ylidene>-α-(2-bromo-5-methoxy-4-methoxymethylphenyl)-acetate 
• 51814-28-9 1-(3-methoxy-4-methylphenyl)-2-propanone 
• 24160-29-0 1-(3-methoxy-4-methyl-phenyl)propan-2-amine 
• 103264-70-6 2-(3-hydroxy-4-methylphenyl)acetonitrile 
• 18149-16-1 1′-(3-methoxy-4-methylphenyl)ethyl-2′-amine 
• 765302-48-5 ethyl 2-(3-hydroxy-4-methylphenyl)acetate 
• 765302-47-4 ethyl 2-(3-methoxy-4-methylphenyl)acetate 
• 1292687-92-3 2-(3-(3-hydroxy-2,6-dimethylbenzyloxy)-4-methylphenyl)acetic acid 
• 1292688-15-3 ethyl 2-(3-(3-hydroxy-2,6-dimethylbenzyloxy)-4-methylphenyl)acetate 
• 1292688-13-1 ethyl 2-(3-(3-(tert-butyldimethylsilyloxy)-2,6-dimethylbenzyloxy)-4-methylphenyl)acetate 

Relevant academic research and scientific papers

Studies on the Synthesis of Heterocyclic Compounds. Part 832. A Simple and Efficient Synthesis of Apomitomycin Derivatives; a Potential Intermediate for Mitomycin Synthesis

Condensation of pyrrolidine-2-thione (21) with methyl α-bromo-(2-bromo-4,5-dimethoxyphenyl)acetate (15) gave methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate (25) in high yield.Several other methyl (Z)-α-aryl-α-acetates (26)-(31) were also synthesised in good yields from reaction of the corresponding phenylacetates (15), (12), and (13) with trans-3-acetoxy-4-(N-ethoxycarbonyl-N-methylamino)pyrrolidine-2-thione (20).Treatment of compounds (25)-(31) with sodium hydride and copper(I) bromide in dimethylformamide afforded methyl 2,3-dihydro-6,7-dimethoxy-1H-pyrroloindole-9-carboxylate (34) and the methyl (+/-)-trans-1-acetoxy-2-(N-ethoxycarbonyl-N-methylamino)-2,3-dihydro-1H-pyrroloindole-9-carboxylates (35)-(37) in good yields.Methyl (+/-)-trans-1-acethoxy-2-(N-ethoxycarbonyl-N-methylamino)-2,3-dihydro-7-methoxy-6-methyl-1H-pyrroloindole-9-carboxylate (36) was converted into the 5,8-quinone (3), via the 8-nitro-compound (38).