4686-21-9

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 88919-97-5 N-methoxymethyl-4-nitroaniline 
• 7507-66-6 1,3,5-tris(4-nitrophenyl)-1,3,5-hexahydrotriazine 
• 50-00-0 formaldehyd 
• 100-01-6 4-nitro-aniline 

Relevant academic research and scientific papers

Copper-Catalyzed three- Five- or seven-Component coupling reactions: The selective synthesis of cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines based on a strecker-type synthesis

We have demonstrated that a cooperative catalytic system comprised of CuCl and Cu(OTf)2 could be used to effectively catalyse the three-, five- and seven-component coupling reactions of aliphatic or aromatic amines, formaldehyde, and trimethylsilyl cyanide (TMSCN), and selectively produce in good yields the corresponding cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines.

TiCl4 induced N-methyleneamine equivalents: A new route to aminoacetonitriles

TiCl4 induced N-methyleneamine equivalents from hexahydro-1,3,5-triazines or N-(methoxymethyl)amines were reacted with trimethylsilyl cyanide to give aminoacetonitriles in 40-90% yield.