468741-02-8

Basic information

• Product Name: 4-aMino-3-Methyl-5-nitro-benzonitrile
• Synonyms: 4-aMino-3-Methyl-5-nitro-benzonitrile;4-AMino-5-Methyl-3-nitrobenzonitrile
• CAS NO: 468741-02-8
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16008
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 468741-02-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-aMino-3-Methyl-5-nitro-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aMino-3-Methyl-5-nitro-benzonitrile(468741-02-8)
• EPA Substance Registry System: 4-aMino-3-Methyl-5-nitro-benzonitrile(468741-02-8)

Safety Data

• Hazardous Substances Data: 468741-02-8(Hazardous Substances Data)

Upstream product

• 557-21-1 zinc(II) cyanide 
• 77811-44-0 4-bromo-2-methyl-6-nitroaniline 
• 557-21-1 dicyanozinc 
• 78881-21-7 4-amino-3-methylbenzonitrile 
• 943634-40-0 N-(4-cyano-2-methylphenyl)-2,2,2-trifluoroacetamide 
• 468741-01-7 N-(4-cyano-2-methyl-6-nitro-phenyl)-2,2,2-trifluoro-acetamide 
• 96784-54-2 3-methyl-4-nitrobenzonitrile 

Downstream Products

• 468741-03-9 3,4-diamino-5-methyl-benzonitrile 
• 1329119-25-6 2-(2-chloro-6-fluoro-phenyl)-7-methyl-1H-benzimidazole-5-carbonitrile 
• 1329119-26-7 2-(2-chloro-6-fluoro-phenyl)-7-methyl-1H-benzimidazole-5-carbaldehyde 
• 468741-39-1 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester 
• 468739-80-2 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid amide 
• 468741-41-5 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid 

Relevant articles and documents

ROR NUCLEAR RECEPTOR MODULATORS

The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.

NOVEL BENZIMIDAZOLE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel benzimidazole compound, a pharmaceutical composition for preventing or treating an inflammatory disease comprising said compound, a use of a novel benzimidazole compound for the manufacture of a medicament for prev

Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile

A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.

Benzimidazole C-2 heterocycles as kinase inhibitors

Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer.

Novel tyrosine kinase inhibitors

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.