468741-02-8

Basic information

• Product Name: 4-aMino-3-Methyl-5-nitro-benzonitrile
• Synonyms: 4-aMino-3-Methyl-5-nitro-benzonitrile;4-AMino-5-Methyl-3-nitrobenzonitrile
• CAS NO: 468741-02-8
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16008
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 468741-02-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-aMino-3-Methyl-5-nitro-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aMino-3-Methyl-5-nitro-benzonitrile(468741-02-8)
• EPA Substance Registry System: 4-aMino-3-Methyl-5-nitro-benzonitrile(468741-02-8)

Safety Data

• Hazardous Substances Data: 468741-02-8(Hazardous Substances Data)

Usage

Description

4-aMino-3-Methyl-5-nitro-benzonitrile is an organic compound that serves as an intermediate in the synthesis of novel benzimidazoles. It plays a crucial role in the development of pharmaceuticals targeting specific receptors.
Used in Pharmaceutical Industry:
4-aMino-3-Methyl-5-nitro-benzonitrile is used as a chemical intermediate for the synthesis of benzimidazoles that act as inhibitors of insulin-like growth factor receptor-1 (IGF-1R). These benzimidazoles have potential applications in the treatment of various diseases and conditions by targeting and modulating the activity of IGF-1R.

Upstream product

• 557-21-1 zinc(II) cyanide 
• 77811-44-0 4-bromo-2-methyl-6-nitroaniline 
• 557-21-1 dicyanozinc 
• 78881-21-7 4-amino-3-methylbenzonitrile 
• 96784-54-2 3-methyl-4-nitrobenzonitrile 
• 943634-40-0 N-(4-cyano-2-methylphenyl)-2,2,2-trifluoroacetamide 
• 468741-01-7 N-(4-cyano-2-methyl-6-nitro-phenyl)-2,2,2-trifluoro-acetamide 

Downstream Products

• 468741-03-9 3,4-diamino-5-methyl-benzonitrile 
• 1329119-25-6 2-(2-chloro-6-fluoro-phenyl)-7-methyl-1H-benzimidazole-5-carbonitrile 
• 1329119-26-7 2-(2-chloro-6-fluoro-phenyl)-7-methyl-1H-benzimidazole-5-carbaldehyde 
• 468741-39-1 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester 
• 468739-80-2 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid amide 
• 468741-41-5 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid 
• 468734-63-6 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile 

Relevant articles and documents

ROR NUCLEAR RECEPTOR MODULATORS

The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.

HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS

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Benzimidazole C-2 heterocycles as kinase inhibitors

Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer.