468741-03-9

Upstream product

• 468741-02-8 4-amino-3-methyl-5-nitrobenzonitrile 
• 943634-40-0 N-(4-cyano-2-methylphenyl)-2,2,2-trifluoroacetamide 
• 468741-01-7 N-(4-cyano-2-methyl-6-nitro-phenyl)-2,2,2-trifluoro-acetamide 
• 96784-54-2 3-methyl-4-nitrobenzonitrile 
• 78881-21-7 4-amino-3-methylbenzonitrile 
• 77811-44-0 4-bromo-2-methyl-6-nitroaniline 

Downstream Products

• 1329119-25-6 2-(2-chloro-6-fluoro-phenyl)-7-methyl-1H-benzimidazole-5-carbonitrile 
• 1329119-26-7 2-(2-chloro-6-fluoro-phenyl)-7-methyl-1H-benzimidazole-5-carbaldehyde 
• 468741-39-1 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester 
• 468739-80-2 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid amide 
• 468741-41-5 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid 
• 468734-63-6 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile 

Relevant academic research and scientific papers

NOVEL BENZIMIDAZOLE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel benzimidazole compound, a pharmaceutical composition for preventing or treating an inflammatory disease comprising said compound, a use of a novel benzimidazole compound for the manufacture of a medicament for prev

Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile

A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.

Benzimidazole C-2 heterocycles as kinase inhibitors

Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer.

Novel tyrosine kinase inhibitors

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.