46884-05-3

Upstream product

• 100-39-0 benzyl bromide 
• 2818-69-1 5-chloro-2-methyl-1H-benzimidazole 
• 39235-92-2 4-chloro-N1-(phenylmethyl)-1,2-benzenediamine 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 84859-34-7 3-{1-[(E)-2-Benzylamino-5-chloro-phenylimino]-ethyl}-4-hydroxy-6-methyl-pyran-2-one 

Downstream Products

• 156212-78-1 1-Benzyl-5-chloro-1H-benzoimidazole-2-carbaldehyde 
• 156212-84-9 (E)-3-(1-Benzyl-5-chloro-1H-benzoimidazol-2-yl)-acrylic acid ethyl ester 
• 156212-92-9 3-(1-Benzyl-5-chloro-1H-benzoimidazol-2-yl)-propionic acid ethyl ester 

Relevant academic research and scientific papers

Design and synthesis of 3-(benzimidazol-2-yl)-propionic acids as thromboxane A2 receptor antagonists

A series of 3-(benzimidazol-2-yl)-propionic acids substituted at the N1 nitrogen with methyl and benzyl groups and at the C5 and C6 positions with chloro, methoxy, amino, hydroxyl groups were synthesized and tested as TXA2 receptor antagonists.

Condensation of o-Diamines with Dehydroacetic Acid and Pyrolysis of Resultant Products

Condensation of o-phenylenediamines with dehydroacetic acid (I) yields 3--4-hydroxy-6-methyl-2(H)-pyrones (II), which on pyrolysis give the corresponding 2-methylbenzimidazoles (V).