46885-71-6

Upstream product

• 51-17-2 benzoimidazole 
• 824-94-2 p-methoxybenzyl chloride 
• 706785-07-1 4,5-diethynyl-1-(4-methoxy-benzyl)-1H-imidazole 
• 104-01-8 4-Methoxyphenylacetic acid 
• 615-36-1 2-bromoaniline 
• 53746-69-3 N,N-Dimethyl-N'-2-bromphenylformamidin 
• 2393-23-9 4-methoxy-benzylamine 
• 74739-48-3 (E)-N-(2-chlorophenyl)-N,N-dimethylformamidine 

Downstream Products

• 1569410-48-5 dichloro-(N-(4-methoxybenzyl)benzimidazole)(p-cymene)ruthenium 
• 1341164-81-5 1-(4-methoxybenzyl)-3-methyl-1H-benzimidazol-3-ium iodide 
• 1341165-05-6 1-(4-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one 

Relevant academic research and scientific papers

Decarboxylative Csp3 -N Bond Formation by Electrochemical Oxidation of Amino Acids

Decarboxylative Csp3-N coupling reactions have been developed through electrochemical oxidation of amino acids. The reaction proceeds via anodic oxidative decarboxylation of carboxylic acids to form stabilized carbocations, which are

Convenient synthesis of N-1-alkyl benzimidazoles via Pd catalyzed C–N bond formation and cyclization

N-1-Alkyl-2-unsubstituted benzimidazoles were directly synthesized by intermolecular coupling of formimidamides with benzylamines; the syntheses were catalyzed by Pd(OAc)2 in one pot, giving rise to moderate to good yields. Aromatic formamidine

Method for synthesizing metal-catalyzed 1-benzylamino substituted benzimidazole

The invention provides a method for synthesizing metal-catalyzed 1-benzylamino substituted benzimidazole, and the metal-catalyzed 1-benzylamino substituted benzimidazole is prepared from raw materialso-halogenated aryl N, N-dimethylformamidine or a deriva

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). dCTPase is highly expressed in multiple carcinomas and is associated with cancer cell stemness. Here we report on the development of the first potent and selective dCTPase inhibitors that enhance the cytotoxic effect of cytidine analogues in leukemia cells. Boronate 30 displays a promising in vitro ADME profile, including plasma and mouse microsomal half-lives, aqueous solubility, cell permeability and CYP inhibition, deeming it a suitable compound for in vivo studies.

Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling

Electron poor benzimidazole substrates were arylated via an intramolecular cross-dehydrogenative coupling (CDC) reaction. These CDC reactions were catalyzed by a Pd(II)/Cu(I) catalyst system, capable of producing moderate yields on a large library of substrates. The substrate scope consisted of tethered arene-benzimidazoles that upon coupling, produced a fused polycyclic motif.

The first used half sandwich ruthenium(II) complexes bearing benzimidazole moiety for N-alkylation of amines with alcohols This paper is dedicated to Professor Irina P. Beletskaya on the occasion of her contribution to catalysis.

Half sandwich ruthenium(II) complexes were synthesized from [RuCl 2(η6-p-cymene)]2 and N-substituted benzimidazole. All new compounds were characterized by elemental analysis, 1H NMR, 13C NMR, and IR spectroscopy. Aminoarenes were readily converted into secondary amines by the reaction at 150 C with benzyl alcohol and in the presence of a catalytic amount of novel ruthenium complexes. All of [RuCl2(η6-p-cymene)(N-substituted benzimidazole)] complexes were the most effective catalyst for N-alklyation reaction using borrowing hydrogen methodology.

Bergman cycloaromatization of imidazole-fused enediynes: The remarkable effect of N-aryl substitution

A series of N-aryl substituted 'imidazole-fused' (Z) 3-ene-1,5-diynes was prepared and kinetic parameters for their Bergman cycloaromatization reactivities were determined. N-Arylation enhanced rates relative to N-alkyl derivatives by up to sevenfold (ANOVA p0.0001). The greatest enhancement was exhibited by the N-phenyl derivative (sevenfold at 145°C).

5,10,15,20-Tetrakis(N-protected-imidazol-2-yl)porphyrins

It is shown that examples of title porphyrins can be prepared from suitably N-protected imidazole-2-carboxaldehydes and pyrrole in refluxing propionic acid: subsequent deprotection, affords a synthetic route to 5,10,15,20-tetrakis(substituted-imadizol-2-y) porphyrins (TIPs).