469-23-8Relevant articles and documents
A formal asymmetric synthesis of Calabar bean alkaloids
Node, Manabu,Hao, Xiao-Jiang,Nishide, Kiyoharu,Fuji, Kaoru
, p. 715 - 719 (1996)
A total synthesis of (-)-eserethole (2) has been accomplished using the Diels-Alder reaction of (S)-(-)-methyl-2-[2-(E)-nitroethenyl]-δ- valerolactone (3) and Danishefsky's diene as a key step. The synthesis of optically pure (-)-eserethole (2) constitutes a formal synthesis of naturally occurring Calabar bean alkaloids such as (-)-physostigmine (1), (-)- physovenine (17) and (-)-geneserine (18).