4691-71-8

Basic information

• Product Name: 4-cyano-2-hydroxybenzoic acid
• Synonyms: 4-cyano-2-hydroxybenzoic acid
• CAS NO: 4691-71-8
• Molecular Formula: C₈H₅NO₃
• Molecular Weight: 163.1302
• Mol File: 4691-71-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-cyano-2-hydroxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyano-2-hydroxybenzoic acid(4691-71-8)
• EPA Substance Registry System: 4-cyano-2-hydroxybenzoic acid(4691-71-8)

Safety Data

• Hazardous Substances Data: 4691-71-8(Hazardous Substances Data)

Upstream product

• 619-65-8 4-cyanobenzoic Acid 
• 16870-28-3 4-iodosalicylic acid 
• 65-49-6 4-Aminosalicylic acid 

Downstream Products

• 1229617-77-9 4-(4-fluorophenyl)-2-oxo-2H-chromene-7-carbonitrile 
• 2372-50-1 4-Aminomethyl-2-hydroxy-benzoessaeureethylester 

Relevant articles and documents

Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids

A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.

Study of the chemoselectivity of Grignard reagent addition to substrates containing both nitrile and Weinreb amide functionalities

Several substrates containing both cyano and Weinreb amide functionalities have been synthesized to study the chemoselectivity of their reactions with organomagnesium bromides (ArMgBr and RMgBr). Excellent chemoselectivity towards the Weinreb amide was observed in most cases, even in the presence of excess Grignard reagent, affording cyano ketones in good-to-excellent yields. The reactions of various substrates containing both nitrile and Weinreb amide functionalities with Grignard reagents have been studied. The Weinreb amide reacts chemoselectively with excess Grignard reagent to give the corresponding cyano ketones in good yields. This chemoselectivity has been exploited for the synthesis of a key coumarin intermediate towards the 5-lipoxygenase inhibitor MK-0633. Copyright

Pd(II)-catalyzed hydroxylation of arenes with 1 atm of O2 or air

(Chemical Equation Presented) Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under 1 atm of O2 or air is achieved under nonacidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.