46926-44-7Relevant articles and documents
Synthesis and Evaluation of a Series of Bis(pentylpyridinium) Compounds as Antifungal Agents
Obando, Daniel,Koda, Yasuko,Pantarat, Namfon,Lev, Sophie,Zuo, Xiaoming,Bijosono Oei, Johanes,Widmer, Fred,Djordjevic, Julianne T.,Sorrell, Tania C.,Jolliffe, Katrina A.
, p. 1421 - 1436 (2018/07/29)
A series of bis(4-pentylpyridinium) compounds with a variety of spacers between the pyridinium headgroups was synthesised, and the antifungal activity of these compounds was investigated. Lengthening the alkyl spacer between the pentylpyridinium headgroups from 12 to 16 methylene units resulted in increased antifungal activity against C. neoformans and C. albicans, but also resulted in increased hemolytic activity and cytotoxicity against mammalian cells. However, inclusion of an ortho-substituted benzene ring in the centre of the alkyl spacer resulted in decreased cytotoxicity and hemolytic activity, while maintaining antifungal potency. Replacement of the alkyl and aromatic-containing spacers by more hydrophilic ethylene glycol groups resulted in a loss of antifungal activity. Some of the compounds inhibited fungal PLB1 activity, but the low correlation of this inhibition with antifungal potency indicates PLB1 inhibition is unlikely to be the predominant mode of antifungal action of this class of compounds, with preliminary studies suggesting they may act via disruption of fungal mitochondrial function.
Synthesis of planar-chiral paracyclophanes via samarium(II)-catalyzed intramolecular pinacol coupling
Ueda, Tsuyoshi,Kanomata, Nobuhiro,Machida, Hajime
, p. 2365 - 2368 (2007/10/03)
(Chemical Equation Presented) A series of [n]jparacyclophanediols (n = 8-12) was synthesized by samarium-catalyzed pinacol coupling for their ansa-bridge formation. Enantiomerically pure [n]jparacyclophane esters were derived from the diols in a several steps via chiral resolution (for n = 10) or via crystallization-induced asymmetric transformation (for n = 11) by using amino alcohol auxiliaries and their selective cleavages.
Rapid Solid-Phase Syntheses of Conjugated Homooligomers and [AB] Alternating Block Cooligomers of Precise Length and Constitution
Huang, Shenlin,Tour, James M.
, p. 8898 - 8906 (2007/10/03)
A new iterative divergent/convergent solid-phase synthesis of precisely defined oligomers is described. The starting monomer is affixed to the solid support so that both ends are free for growth. The polymer-supported n-mer bearing α,ω,-terminal iodides i
A common strategy for the synthesis of (+)-hepialone and (±)-α-lipoic acid
Rao,Rao
, p. 1531 - 1543 (2007/10/02)
A common method starting from a substituted aromatic system is presented for the synthesis of (+)-Hepialone and (±)-α-lipoic acid.
Quaternary ammonium compounds having muscle relaxation activity
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, (2008/06/13)
A quaternary ammonium having a muscle relaxation activity compound represented by the formula (I): STR1 wherein R1 represents a methylene, a lower alkylenoxy, a lower alkenylene, a lower alkynylene, --CO--, --COO--, a lower alkylene carbonyloxy, --CH(OR5)--, a lower alkylenecarbonyl, a hydroxy lower alkylene, --O--, --S--, --SO--, or --SO2 --; R2 represents a hydrogen atom, a hydroxy lower alkyl, an aldehyde, a lower alkyl carbonyl, --NO2, or --NHR6 ; R3 represents a hydrogen atom of a group --R1 --(CH2)a --[CH(CH2 A)--CH2 ]b --A; R4 represents an anion; R5 and R6 represent a hydrogen atom or a acetyl; A represents a quaternary ammonium group; a represents an integer of 1 to 8; b represents 0 or 1; m represents an integer of 1 to 4; and (Z) represents a trivalent benzene ring, a trivalent naphthalene ring, a trivalent diphenyl or a trivalent ethane radical.
