4693-18-9

Usage

Uses

Used in Fragrance and Flavor Industry:
1-Hexanone, 1-(2,5-dihydroxyphenyl)is used as a key ingredient in the manufacturing of fragrances and flavors due to its pleasant floral scent, enhancing the sensory experience of various products.
Used in Pharmaceutical Industry:
1-Hexanone, 1-(2,5-dihydroxyphenyl)is used as a potential anti-cancer agent for its ability to target and inhibit the growth of cancer cells, offering a novel therapeutic approach in oncology.
Used in Antiviral Applications:
1-Hexanone, 1-(2,5-dihydroxyphenyl)is used as a potential anti-viral agent, leveraging its properties to inhibit viral replication and reduce the severity of viral infections.
Used in Nutraceutical Industry:
1-Hexanone, 1-(2,5-dihydroxyphenyl)is used as a nutraceutical ingredient for its antioxidant and anti-inflammatory properties, contributing to the development of health supplements and functional foods that promote overall well-being and reduce the risk of chronic diseases.

Upstream product

• 142-61-0 Hexanoyl chloride 
• 123-31-9 hydroquinone 
• 142-62-1 hexanoic acid 
• 66-25-1 hexanal 
• 106-51-4 p-benzoquinone 

Downstream Products

• 140466-94-0 1-(5-Dodecyloxy-2-hydroxy-phenyl)-hexan-1-one 
• 4197-72-2 2-hexylhydroquinone 
• 13183-93-2 2-Hexyl-5-sulfo-hydrochinon 
• 65781-67-1 2-Hexanoyl-1,4-benzochinon 

Relevant academic research and scientific papers

Half-wave potentials and in vitro cytotoxic evaluation of 3-acylated 2,5-bis(phenylamino)-1,4-benzoquinones on cancer cells

A broad range of 3-acyl-2,5-bis(phenylamino)-1,4-benzoquinones were synthesized and their voltammetric values, as well as in vitro cancer cell cytotoxicities, were assessed. The members of this series were prepared from acylbenzoquinones and phenylamines, in moderate to good yields (47-74%), through a procedure involving a sequence of two in situ regioselective oxidative amination reactions. The cyclic voltammograms of the aminoquinones exhibit two one-electron reduction waves to the corresponding radical-anion and dianion, and two quasi-reversible oxidation peaks. The first and second half-wave potential values (E1/2) of the members of the series were sensitive to the push-pull electronic effects of the substituents around the benzoquinone nucleus. The in vitro cytotoxic activities of the 3-acyl-2,5-bis(phenylamino)-1,4-benzoquinones against human cancer cells (bladder and prostate) and non-tumor human embryonic kidney cells were measured using the MTT colorimetric method. The substitution of both aniline groups, by either methoxy (electron donating effect) or fluorine (electron withdrawal effect), decreased the cytotoxicity in the aminoquinones. Among the members of the unsubstituted phenylamino series, two of the 18 compounds showed interesting anti-cancer activities. A preliminary assay, looking for changes in the expression of selected genes, was performed. In this context, the two compounds increased TNF gene expression, suggesting an association with an inflammatory-like response.