4693-38-3

Basic information

• Product Name: 3-CHLORO-1-(3,4-DIMETHOXYPHENYL)PROPAN-1-ONE
• Synonyms: 1-Propanone, 3-chloro-1-(3,4-diMethoxyphenyl)-;NSC 55772;3-CHLORO-3',4'-DIMETHOXYPROPIOPHENONE;3-CHLORO-1-(3,4-DIMETHOXYPHENYL)PROPAN-1-ONE;AKOS 225-15;1-CHLORO-3-(3,4-DIMETHOXYPHENYL)-3-OXOPROPANE
• CAS NO: 4693-38-3
• Molecular Formula: C₁₁H₁₃ClO₃
• Molecular Weight: 228.67
• Mol File: 4693-38-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 348.7°Cat760mmHg
• Flash Point: 145.7°C
• Appearance: /
• Density: 1.161
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-CHLORO-1-(3,4-DIMETHOXYPHENYL)PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1-(3,4-DIMETHOXYPHENYL)PROPAN-1-ONE(4693-38-3)
• EPA Substance Registry System: 3-CHLORO-1-(3,4-DIMETHOXYPHENYL)PROPAN-1-ONE(4693-38-3)

Safety Data

• Hazardous Substances Data: 4693-38-3(Hazardous Substances Data)

Usage

General Description

3-CHLORO-1-(3,4-DIMETHOXYPHENYL)PROPAN-1-ONE is a chemical compound with the molecular formula C11H13ClO3. It is a ketone with a chloro and a dimethoxy group attached to a propyl chain. 3-CHLORO-1-(3,4-DIMETHOXYPHENYL)PROPAN-1-ONE is used in the synthesis of pharmaceuticals and organic compounds, as well as in research and development. It is important to handle this chemical with care and follow safety protocols, as it can be hazardous if not used properly.

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 625-36-5 2-chloropropionyl chloride 
• 186581-53-3 diazomethane 

Downstream Products

• 120014-07-5 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 33731-40-7 1-(3,4-dimethoxyphenyl)prop-2-en-1-one 
• 2107-69-9 5,6-dimethoxy-1-indanone 
• 1567-99-3 3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

Unravelling the potency of triazole analogues for inhibiting α-synuclein fibrillogenesis andin vitrodisaggregation

A series of triazole-based compounds was synthesized using a click chemistry approach and evaluated for the inhibition of α-synuclein (α-syn) fibrillogenesis and its disaggregation. CompoundsTr3,Tr7,Tr12,Tr15, andTr16exhibited good effect in inhibiting α-

Mechanistic studies of base-catalysed lignin depolymerisation in dimethyl carbonate

The depleting fossil reservoirs have stimulated global research initiatives on renewable lignin feedstocks as sustainable alternatives to petroleum-derived aromatics. Base-catalysed depolymerisation (BCD) is regarded as an economical and efficient approach for the valorisation of technical lignins. The major limiting factor encountered during this process is the re-condensation of the formed phenolic products, which results in lower monomer yields. To diminish these side reactions, we selected alkali earth metal catalysts in dimethyl carbonate (DMC) to produce methylated phenol derivatives as the final products. Herein, we demonstrate for the first time a base-promoted depolymerisation process affording low-molecular weight oils in high yields (52-67 wt%) wherein the employed bases are used in truly catalytic quantities (with catalyst loadings of around 5 mol%). The general applicability of this methodology was proved on four different lignin samples (1 Kraft, 3 organosolv) using caesium carbonate and lithium tert-butoxide as catalysts. The 2D NMR studies on the post-reaction lignin samples showed a similar degradation of the major lignin linkages for both bases. A difference in the reduction of phenolic moieties was revealed by quantitative 31P NMR analysis. Furthermore, GPC analysis demonstrated a significant shift towards lower mass fragments for the Cs2CO3-catalysed lignin degradation. A detailed GC-MS analysis for these samples identified a range of methoxy capped-monomeric degradation products. The scope of this reaction system was further expanded to lignocellulosic biomass such as milled beechwood chips, which notably showed similar product distributions. Based on the correlation of the experimental observations for extracted lignin samples and model compound studies, a mechanistic pathway for the Cs2CO3-catalysed system was suggested. DFT calculations provided reaction pathways for the observed cleavage products.

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