4694-11-5Relevant academic research and scientific papers
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
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Page/Page column 1036-1038, (2021/02/10)
The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
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Paragraph 4771; 4772, (2016/05/02)
The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
Trisubstituted Stannyllithium as a Double Electron Equivalent. Reaction with α,β-Enones
Sato, Tadashi,Watanabe, Masami,Watanabe, Toshiyuki,Onoda, Yasuo,Murayama, Eigoro
, p. 1894 - 1899 (2007/10/02)
β-Stannyl ketones, easily available by the conjugate addition of (trimethylstannyl)lithium to α,β-enones, produced two types of ketones depending upon the substitution pattern by the treatment with titanium(IV) chloride.All the reactions proceeded through an intermediacy of cyclopropanol derivatives.The reaction involving the carbon skeleton rearrangement is promising as a synthetic method.
THE REACTION OF β-STANNYL CARBONYL COMPOUNDS WITH LEWIS ACIDS
Sato, Tadashi,Watanabe, Masami,Murayama, Eigoro
, p. 1621 - 1624 (2007/10/02)
β-Stannyl carbonyl compounds, when treated with Lewis acids, afforded cyclopropane derivatives or ketones, and the reaction was applied to the synthesis of β,γ-enones from α,β-enones.
