47016-79-5

Upstream product

• 143666-76-6 N-benzyl-N-methyl-(4-nitrophenoxy)acetylamide 
• 19076-89-2 ethyl 4-nitrophenoxyacetate 
• 1798-11-4 4-nitrophenoxyacetic acid 
• 20142-88-5 2-(4-nitrophenoxy)acetyl chloride 
• 100-02-7 4-nitro-phenol 
• 143666-84-6 2-(4-Amino-phenoxy)-N-benzyl-N-methyl-acetamide 

Relevant academic research and scientific papers

Synthesis and Activity against Multidrug Resistance in Chinese Hamster Ovary Cells of New Acridone-4-carboxamides

A number of tricyclic carboxamides have been synthesized and tested to evaluate their ability to reverse multidrug resistance in the CHRC/5 cell line.Among them the acridone derivatives were the most potent.A key feature is the presence of a dimethoxybenzyl or phenethylamine cationic site, separated from the tricyclic lipophilic part by a carbamoylphenyl chain.Optimization led to compounds 2 orders of magnitude more active than the prototype inhibitors verapamil and amiodarone.On the basis of in vitro and in vivo activities, 9,10-dihydro-5-methoxy-9-oxo-N-phenyl>-4-acridinecarboxamide (84) has been selected for further development.