470465-79-3Relevant academic research and scientific papers
Pharmaceutical uses and synthesis of nicotinamides
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Page/Page column 31, (2010/02/08)
A compound of the formula and pharmaceutically acceptable salts thereof, wherein R1is selected from (R3)C(═O)—N(R4)— and (R3)(R4)N—C(═O)—; R2is selected from —OR5and —N(R5)(R6); n is 0, 1, 2 or 3; X is selected from oxygen and sulfur; and R3, R4, R5and R6are independently selected from hydrogen, alkyl, heteroalkyl, aryl, aryl(akylene), heteroaryl, heteroaryl(alkylene), carbocycle, carbocycle(alkylene), heterocycle, and heterocycle(alkylene); as well as pharmaceutical compositions containing said compound. The compounds and compositions are useful in, for example, the treatment of inflammatory events in an animal subject.
Nicotinanilides as inhibitors of neutrophil chemotaxis
Cutshall, Neil S.,Kucera, Kristin A.,Ursino, Rocky,Latham, John,Ihle, Nathan C.
, p. 1517 - 1520 (2007/10/03)
A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-α-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic
