470470-76-9

Upstream product

• 147252-93-5 (3S)-3-(benzyloxy)-2,2-dimethyl-4-penten-1-ol 
• 20374-33-8 (R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on 
• 277317-84-7 (2R/S,3R)-3-(Benzyloxy)tetrahydro-4,4-dimethylfuran-2-ol 
• 1352746-56-5 (2R)-1-tert-butyldimethylsilyloxy-4-(trimethylsilylmethyl)-pent-4-en-2-ol 
• 470470-69-0 (5S,7R,9S)-5,11-dibenzyloxy-4,4-dimethyl-7,9-dihydroxy-7,9-O-isopropylideneundec-1-yn-3-one 
• 470470-84-9 (S)-5-Benzyloxy-6-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-4,4-dimethyl-hex-1-yn-3-ol 
• 470470-68-9 (S)-3-Benzyloxy-4-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2,2-dimethyl-butyraldehyde 
• 470470-63-4 (S)-3-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentan-1-ol 
• 470470-64-5 (S)-3-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentanal 
• 470470-82-7 ((S)-3-benzyloxy-2,2-dimethyl-pent-4-enyloxy)-tert-butyl-dimethyl-silane 
• 599-04-2 (R)-Pantolacton 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 470470-75-8 (2S,6R)-2-{(2S,4S,6S)-4-Benzyloxy-6-[(S)-4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methoxy-3,3-dimethyl-tetrahydro-pyran-2-ylmethyl}-6-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxymethyl-tetrahydro-pyran-4-ol 
• 470470-71-4 (3S,5R,7S,15R,10E)-1,7-dibenzyloxy-15,16-bis-(tert-butyldimethylsilyloxy)-3,5-dihydroxy-8,8-dimethyl-3,5-O-isopropylidene-13-((E)-trimethylsilylmethylidene)hexadec-10-en-9-one 

Relevant academic research and scientific papers

Synthesis of the C(1)-C(16) fragment of bryostatins using an 'ene' reaction between an allylsilane and an alkynone

The zinc(II) iodide mediated 'ene' reaction between (4R)-4,5-bis-(tert- butyldimethylsilyloxy)-2-(trimethylsilylmethyl)pent-1-ene (43) and (5S,7R,9S)-5,11-dibenzyloxy-4,4-dimethyl-7,9-dihydroxy-7,9-O- isopropylideneundec-1-yn-3-one (53) gave the (E)-vinyl

Synthesis of the C(1)-C(16) fragment of bryostatins

A synthesis of the C(1)-C(16) fragment 43 of the bryostatins is reported which features a stereoselective equivalent of an 'ene' reaction between the allylsilane 35 and the alkynone 33 and the stereoselective conjugate addition-cyclisation of the dienyl k