470689-99-7

Basic information

• Product Name: [1,4'-Bipiperidine]-1'-carboxylic acid, 4-(diphenylamino)-4'-methyl-, 1,1-dimethylethyl ester
• CAS NO: 470689-99-7
• Molecular Formula: C28H39N3O2
• Molecular Weight: 449.637
• Mol File: 470689-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1,4'-Bipiperidine]-1'-carboxylic acid, 4-(diphenylamino)-4'-methyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,4'-Bipiperidine]-1'-carboxylic acid, 4-(diphenylamino)-4'-methyl-, 1,1-dimethylethyl ester(470689-99-7)
• EPA Substance Registry System: [1,4'-Bipiperidine]-1'-carboxylic acid, 4-(diphenylamino)-4'-methyl-, 1,1-dimethylethyl ester(470689-99-7)

Safety Data

• Hazardous Substances Data: 470689-99-7(Hazardous Substances Data)

Upstream product

• 470689-98-6 4-diphenylaminopiperidine-1-carboxylic acid tert-butyl ester 
• 84359-50-2 N,N-diphenylpiperidine-4-amine 
• 62-53-3 aniline 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 125541-22-2 1-(tert-butoxycarbonyl)-4-phenylaminopiperidine 
• 75-16-1 methylmagnesium bromide 
• 685530-67-0 4'-cyano-4-diphenylamino-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 

Downstream Products

• 470689-97-5 (4'-methyl-[1,4']bipiperidinyl-4-yl)diphenylamine 

Relevant articles and documents

Orally Bioavailable Competitive CCR5 Antagonists

The chemokine receptor CCR5 plays an important role in inflammatory and autoimmune disorders as well as in transplant rejection by affecting the trafficking of effector T cells and monocytes to diseased tissues. Antagonists of CCR5 are believed to be of potential therapeutic value for the disorders mentioned above and HIV infection. Here we report on the structure-activity relationship of a new series of highly potent and selective competitive CCR5 antagonists. While all compounds tested were inactive on rodent CCR5, this series includes compounds that cross-react with the cynomolgus monkey (cyno) receptor. One of these compounds, i.e., 26n, has good PK properties in cynos, and its overall favorable profile makes it a promising candidate for in vivo profiling in transplantation and other disease models.