4709-56-2

Usage

General Description

1H-Indene-3-acetic acid, ethyl ester, also known as ethyl 1H-indene-3-carboxylate, is a chemical compound commonly used in the synthesis of pharmaceuticals and organic compounds. It is a clear, colorless liquid with a fruity odor and is insoluble in water. 1H-Indene-3-acetic acid, ethyl ester is often used as a flavoring agent and fragrance ingredient in the manufacturing of perfumes, soaps, and cosmetics. It also has potential applications in the field of medicine and agriculture, as it exhibits anti-inflammatory and plant growth regulating properties. Additionally, 1H-Indene-3-acetic acid, ethyl ester is used as an intermediate in the production of pesticides, herbicides, and other agricultural chemicals due to its ability to influence plant growth and development.

Upstream product

• 105-36-2 ethyl bromoacetate 
• 83-33-0 inden-1-one 
• 28002-99-5 1-(ethoxycarbonyl)methyleneindane 
• 1620-02-6 1-Ethoxycarbonylmethyl-1-hydroxy-indan 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 1620-00-4 1H-indene-3-acetic acid 
• 22339-45-3 2,3-dihydro-1H-indene-1-acetic acid ethyl ester 

Relevant academic research and scientific papers

Biological effects on μ-receptors affinity and selectivity of aryl propenyl chain structural modification on diazatricyclodecane derivatives

Opioid analgesics are clinically used to relieve severe pain in acute postoperative and cancer pain, and also in the long term in chronic pain. The analgesic action is mediated by μ-, δ-, and κ-receptors, but currently, with few exceptions for k-agonists,

Diastereo- and Enantioselective Catalytic Radical Oxysulfonylation of Alkenes in β,γ-Unsaturated Ketoximes

The asymmetric radical-initiated difunctionalization of internal alkenes, which creates two vicinal stereocenters, has been a significant synthetic challenge despite the tremendous progress achieved for terminal alkenes. This is attributable to the common

PLANT GROWTH REGULATOR COMPOUNDS

The present invention relates to relates to novel strigolactone derivatives of formula (I), to processes for preparing these derivatives including intermediate compounds, to seeds comprising these derivatives, to plant growth regulator or seed germination promoting compositions comprising these derivatives and to methods of using these derivatives in controlling the growth of plants and/or promoting the germination of seeds.

Design and synthesis of conformationally constrained analogues of cis-cinnamic acid and evaluation of their plant growth inhibitory activity

1-O-cis-Cinnamoyl-β-d-glucopyranose is known to be one of the most potent allelochemical candidates and was isolated from Spiraea thunbergii Sieb by Hiradate et al. (2004), who suggested that it derived its strong inhibitory activity from cis-cinnamic acid, which is crucial for phytotoxicity. In this study, key structural features and substituent effects of cis-cinnamic acid (cis-CA) on lettuce root growth inhibition was investigated. These structure-activity relationship studies indicated the importance of the spatial relationship of the aromatic ring and carboxylic acid moieties. In this context, conformationally constrained cis-CA analogues, in which the aromatic ring and cis-olefin were connected by a carbon bridge, were designed, synthesized, and evaluated as plant growth inhibitors. The results of the present study demonstrated that the inhibitory activities of the five-membered and six-membered bridged compounds were enhanced, up to 0.27 μM, and were ten times higher than cis-CA, while the potency of the other compounds was reduced.

Potassium Channel Modulators

Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein R1, R2, R3, R4, and R5 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin

Synthesis of trans-fused lactones containing the indane nucleus has resulted in a series of potent acylating inhibitors of thrombin. As an example compound 11e has an apparent second order rate constant of 11 x 106 M-1 sec-1 for the inhibition of thrombin. The anticoagulant activity of these compounds is discussed.