471-95-4

Usage

Uses

Used in Pharmaceutical Industry:
Bufotaline is used as an anti-tumor agent for its ability to inhibit tumor growth and proliferation. It has been found to be effective against various types of cancer, making it a promising candidate for cancer treatment and research.
Used in Traditional Medicine:
In addition to its modern pharmaceutical applications, Bufotaline has also been utilized in traditional medicine practices, where it is believed to possess various therapeutic properties, including its anti-tumor effects.
Used in Drug Development:
Due to its potent anti-tumor properties, Bufotaline is also used in the development of new drugs and therapies for cancer treatment. Researchers are continuously exploring its potential and investigating ways to enhance its efficacy and safety for clinical use.

Hazard

Deadly poison.

InChI:InChI=1/C26H36O6/c1-15(27)32-21-13-26(30)20-6-5-17-12-18(28)8-10-24(17,2)19(20)9-11-25(26,3)23(21)16-4-7-22(29)31-14-16/h4,7,14,17-21,23,28,30H,5-6,8-13H2,1-3H3

Upstream product

• 1337864-09-1 bufotalin 3-pimeloylarginine ester 
• 571-31-3 Epietiocholanolone 

Downstream Products

• 474-53-3 5?[(3S,5R,8R,9S,10S,13S)?3?hydroxy?10,13?di?methyl?2,3,4,5,6,7,8,9,10,11,12,13?dodecahydro?1H?cyclopenta[a]phenanthren?17?yl]?2H?pyran?2?one 

Relevant academic research and scientific papers

Unified Total Synthesis of Five Bufadienolides

We report a unified total synthesis of five bufadienolides: bufalin (1), bufogenin B (2), bufotalin (3), vulgarobufotoxin (4), and 3-(N-succinyl argininyl) bufotalin (5). After the steroidal ABCD ring 8 was produced, the D ring was cross-coupled with a 2-pyrone moiety and stereoselectively epoxidized to generate 6. TMSOTf promoted a stereospecific 1,2-hydride shift from 6 to establish the β-oriented 2-pyrone of 19. Functional group manipulations from 19 furnished 1-5, which potently inhibited cancer cell growth.

Studies on cytotoxic constituents from the skin of the toad Bufo bufo gargarizans

To study the chemical composition of the skin of Bufo bufo gargarizans, many kinds of chromatography methods were used in the isolation procedures, while the structures of isolated compounds were determined on the basis of their NMR and MS spectral analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as cinobufotalin 3-nonanedioylarginine ester (8) and bufotalin 3-pimeloylarginine ester (14). Furthermore, 13 known compounds were obtained. Isolated bufadienolides showed significant inhibition effect against SMMC-7721 cell lines in vitro.