471268-15-2Relevant academic research and scientific papers
Chemoselective reactions of N1-methyl-2-hydroxy-3-methylamino-3-phenylpropanamide with electrophiles. Synthesis of chiral hexahydro-4-pyrimidinones and oxazolidines
Hajji, Chakib,Testa, Ma Luisa,Zaballos-García, Elena,Zaragozá, Ramón J,Server-Carrió, Juan,Sepúlveda-Arques, José
, p. 3281 - 3285 (2002)
The reactivity of (2S,3S)-N1-methyl-2-hydroxy-3-methylamino-3-phenylpropanamide 1, containing three nucleophilic centres has been studied against dihaloalkanes and aldehydes. Hexahydro-4-pyrimidinones or oxazolidines were obtained chemoselectively. Experimental results were explained by 'ab initio' calculations.
