47132-19-4

Basic information

• Product Name: 5H-Dibenzo(A,D)cyclohepten-10-ol, 10,11-dihydro-5-(3-(methylamino)propylidene)-, (Z)-
• Synonyms: (Z)-10,11-Dihydro-5-(3-(methylamino)propylidene)-5H-dibenzo(A,D)cyclohepten-10-ol;5H-Dibenzo(A,D)cyclohepten-10-ol, 10,11-dihydro-5-(3-(methylamino)propylidene)-, (Z)-;cis-10-Hydroxy Nortriptyline
• CAS NO: 47132-19-4
• Molecular Formula: C19H21NO
• Molecular Weight: 279.37614
• Product Categories: Amines;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 47132-19-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 88-93°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 5H-Dibenzo(A,D)cyclohepten-10-ol, 10,11-dihydro-5-(3-(methylamino)propylidene)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Dibenzo(A,D)cyclohepten-10-ol, 10,11-dihydro-5-(3-(methylamino)propylidene)-, (Z)-(47132-19-4)
• EPA Substance Registry System: 5H-Dibenzo(A,D)cyclohepten-10-ol, 10,11-dihydro-5-(3-(methylamino)propylidene)-, (Z)-(47132-19-4)

Safety Data

• Hazardous Substances Data: 47132-19-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 47132-19-4 differently. You can refer to the following data:
1. A metabolite of Nortriptyline (N837000).
2. A metabolite of Nortriptyline (N837000)

Upstream product

• 50-48-6 amitryptyline 
• 72-69-5 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine 
• 64520-05-4 (Z)-10-Hydroxyamitriptyline 
• 88086-82-2 Methyl-{3-[10-oxo-10,11-dihydro-dibenzo[a,d]cyclohepten-(5E)-ylidene]-propyl}-carbamic acid 2,2,2-trichloro-ethyl ester 
• 37401-47-1 N,Ndimethyl-3-(10,11-dihydro-10-oxo-5H-dibenzocycloheptene)-Δ^5,γ-propylamine 
• 2099-60-7 {3-[10-Bromo-dibenzo[a,d]cyclohepten-(5E)-ylidene]-propyl}-dimethyl-amine 
• 1562-53-4 10-bromo-5-(3-dimethylaminopropyl)-5H-dibenzocycloheptene-5-ol 
• 88086-81-1 Dimethyl-{3-[10-piperidin-1-yl-dibenzo[a,d]cyclohepten-(5E)-ylidene]-propyl}-amine 
• 156458-92-3 (Z)-5-γ-bromopropylidene-10,11-dihydro-10-oxo-5H-dibenzocycloheptene 
• 156458-90-1 1-{5-[3-(Tetrahydro-pyran-2-yloxy)-prop-(Z)-ylidene]-5H-dibenzo[a,d]cyclohepten-10-yl}-piperidine 
• 156458-93-4 5-cyclopropyl-10-piperidin-1-yl-5H-dibenzo[a,d]cyclohepten-5-ol 
• 156458-89-8 5-(γ-hydroxypropylidene)-(10,11-dihydro-10-oxo-5H-dibenzo)-cycloheptene 
• 37439-92-2 10-piperidin-1-yl-dibenzo[a,d]cyclohepten-5-one 
• 156458-91-2 5-[3-Bromo-prop-(Z)-ylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol 

Relevant articles and documents

A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples

A novel and efficient strategy for the simultaneous determination of two tricyclic antidepressant (TCA) drugs [amitriptyline (AT), and its main metabolite (nortriptyline; NT)] via a combination of magnetic solid phase extraction (MSPE), and spectrophotometric techniques in serum is suggested. For this purpose, the imidazolium ionic liquid (Imz)-modified Fe3O4@SiO2 nanoparticles (Fe3O4@SiO2-Imz) was employed as an adsorbent for theMSPE. Preconcentration (loadingdesorption) studies were performed under optimized conditions including pH, adsorbent amount, contact time, eluent volume, and desorption time. Afterward, determination of each drug was carried out by specific strategy. Acetaldehyde (AC), and 2,3,5,6-tetrachloro-1,4-benzoquinone (chloranil; CL) were used as chemical reagents for reaction with NT, while AT did not react with these reagents. This method is based on the condensation reaction between secondary amine group of NT and AC to afford an enamine, and subsequently reaction with CL to produce a chlorinated quinone-substituted enamine. The final product exhibited maximum absorption at 556 nm, while the AT was determined at 240 nm. The limits of detections (LODs) for NT and AT in serum sample were obtained as 0.19 and 0.90 ng mL-1, respectively. The limits of quantifications (LOQs) were obtained to be 0.63 and 2.93 ng mL-1 for NT and AT, respectively. A linear range was obtained to be 1 to 5 ng mL-1. Results indicated that the suggested method is applicable for simultaneous determination of NT and AT in serum samples.

Facile synthesis of (R,S)-(Z) and (R,S)-(E)-N-methyl-(10,11-dihydro-10- hydroxy-5H-dibenzo[a,d]cycloheptene)-Δ(5,γ)-propylamine the major metabolites of amitriptyline and nortriptyline

Efficient methods for the syntheses of amines 6b and 9b, the major metabolites of the antidepressant drugs amitriptyline 1a and nortriptyline 1b, are described.