156458-92-3

Usage

Chemical Properties

White Solid

Upstream product

• 156458-93-4 5-cyclopropyl-10-piperidin-1-yl-5H-dibenzo[a,d]cyclohepten-5-ol 
• 37439-92-2 10-piperidin-1-yl-dibenzo[a,d]cyclohepten-5-one 
• 156458-90-1 1-{5-[3-(Tetrahydro-pyran-2-yloxy)-prop-(Z)-ylidene]-5H-dibenzo[a,d]cyclohepten-10-yl}-piperidine 
• 156458-89-8 5-(γ-hydroxypropylidene)-(10,11-dihydro-10-oxo-5H-dibenzo)-cycloheptene 

Downstream Products

• 156458-91-2 5-[3-Bromo-prop-(Z)-ylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol 
• 47132-19-4 (+)-(Z)-10-Hydroxy-Nortriptyline 

Relevant academic research and scientific papers

COMPOSITIONS OF (-)-E-10-OH-NT AND METHODS FOR THEIR SYNTHESIS AND USE

This present disclosure provides compositions comprising E-10-OH-NT metabolites of AT and NT, methods for their synthesis and methods for their use.

Facile synthesis of (R,S)-(Z) and (R,S)-(E)-N-methyl-(10,11-dihydro-10- hydroxy-5H-dibenzo[a,d]cycloheptene)-Δ(5,γ)-propylamine the major metabolites of amitriptyline and nortriptyline

Efficient methods for the syntheses of amines 6b and 9b, the major metabolites of the antidepressant drugs amitriptyline 1a and nortriptyline 1b, are described.