47169-38-0

Upstream product

• 3273-78-7 4-(4-amino-3-nitrophenoxy)-2-nitrophenylamine 
• 3070-87-9 N-[4-(4-acetylamino-3-nitrophenoxy)-2-nitrophenyl]acetamide 
• 1965-09-9 4,4'-dihydroxydiphenyl ether 

Downstream Products

• 1418280-35-9 3,3'-diiodo-4-4'-dihydroxy-diphenyl ether 

Relevant academic research and scientific papers

Halogenated Phenols for Diagnostics, Antioxidant Protection and Drug Delivery

The present invention provides compositions and methods for the targeted delivery, release and/or formation of a drug compound at a target site(s) within the body of an individual, such as a diseased and/or inflamed tissue in the body of the individual. These compositions may comprise a halogenated phenol ring cleavably linked to a core structure of a drug compound. Due to the variety of substituents that may be utilized in forming the different types of linkages, numerous examples of drug compounds linked to a halogenated phenol ring are proposed. The present invention further provides compositions comprising halogenated phenol starting compounds that do not undergo cleavage during a dehalogenation reaction to form a drug compound in a targeted tissue when administered to an individual. Methods of administering these non-cleaving compounds are further provided.

3, 3 - 4, 4 '-' - dinitro production of dihydroxydiphenyl

PROBLEM TO BE SOLVED: To provide a method for producing 3,3'-dinitro-4,4'-dihydroxydiphenyl ether from 4,4'-dihydroxydiphenyl ether with productivity which is high to such a degree that the method can be applied as an industrial production method.SOLUTION: There is provided a method for nitrating 4,4'-dihydroxydiphenyl ether with nitric acid in an aromatic hydrocarbon solvent. The aromatic hydrocarbon solvent preferably is one or two selected from the group consisting of benzene, toluene, xylene and ethylbenzene.

3,3 'dinitroglycerin-4-, 4' -dihydroxydiphenyl ether and purification of 3, dinitroglycerin 3 '-4-, 4' -dihydroxydiphenyl ether production method

PROBLEM TO BE SOLVED: To provide a method for refining 3,3'-dinitro-4,4'-dihydroxydiphenyl ether with high productivity applicable as an industrial production method.SOLUTION: A crude product of 3,3'-dinitro-4,4'-dihydroxydiphenyl ether is subjected to suspension washing with acetone or an acetone aqueous solution. The resulting suspension is filtered, washed and dried to obtain a 3,3'-dinitro-4,4'-dihydroxydiphenyl ether composition reduced in the content of impurities.

HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY

The present invention provides compositions and methods for the administration and targeted delivery, release and/or formation of a drug compound from a halogenated phenol starting compound of the present invention at site(s) within the body of an individual having high FROS, such as within a diseased and/or inflamed tissue. The present invention further provides compositions and methods for the administration of FROS scavenging compounds to an individual to protect cells and tissues from damage that might be caused by FROS. The present invention further provides compositions and methods for the detection of a detectable product, such as an indigo-like compound or other product of a dehalogenation reaction, formed from a compound of the present invention as a measurement or indication of the amount and/or localization of high FROS levels in the body of an individual.