3273-78-7

Upstream product

• 3070-87-9 N-[4-(4-acetylamino-3-nitrophenoxy)-2-nitrophenyl]acetamide 
• 101-80-4 4,4'-oxydiphenylene diamine 
• 2687-41-4 N-[4-(4-aminophenoxy)phenyl]acetamide 
• 100-00-5 4-chlorobenzonitrile 
• 100-02-7 4-nitro-phenol 
• 824-78-2 4-nitrophenol sodium salt 
• 3070-86-8 N-[4-(4-acetylaminophenoxy)phenyl]acetamide 
• 103-90-2 4-acetaminophenol 
• 2687-40-3 4-nitrophenyl 4'-acetamidophenyl ether 
• 101-63-3 bis(4-nitrophenyl)ether 
• 15267-98-8 sodium 4-aminophenolate 
• 6149-33-3 4-(4-nitrophenoxy)aniline 

Downstream Products

• 38490-83-4 3,3'-dinitrodiphenyl ether 
• 2676-59-7 bis(3,4-diaminophenyl)ether 
• 75708-90-6 4-amino-4'-hydroxy-3,3'-dinitrodiphenyl ether 
• 47169-38-0 4,4'-dihydroxy-3,3'-dinitrodiphenyl ether 
• 1403460-74-1 5,5'-oxy-bis[2-(2',4'-dichlorophenyl)-1H-benzimidazole] 
• 1403460-73-0 5,5'-oxy-bis[2-(4'-bromophenyl)-1H-benzimidazole] 
• 1403460-72-9 5,5'-oxy-bis[2-(3'-methoxy-4'-hydroxyphenyl)-1H-benzimidazole] 
• 1403460-71-8 5,5'-oxy-bis[2-(3',4',5'-trimethoxyphenyl)-1H-benzimidazole] 
• 1403460-70-7 5,5'-oxy-bis[2-(3',5'-dimethoxyphenyl)-1H-benzimidazole] 
• 894734-47-5 5,5'-oxy-bis[2-(4'-methoxyphenyl)-1H-benzimidazole] 
• 53357-17-8 C₁₄H₁₀N₄OS₂ 
• 15268-07-2 3,3'-diaminodiphenyl ether 

Relevant academic research and scientific papers

Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents

A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 μmol/L (mononuclear tumor cell line (U937)) and 5.58 μmol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA.

Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy

In this study, a new series of bis-benzimidazole derivatives were designed and synthesized. Most of these new compounds showed significant anti-tumor activity in vitro compared to Hoechst 33258. Among them, the most potent compound 8 had the IC50/su

Highly chemoselective nitration of aromatic amines using the Ph3P/Br2/AgNO3 system

The use of PPh3/Br2/AgNO3 provides a new reagent system for the novel and highly chemoselective nitration of aromatic amines under mild reaction conditions.

Synthesis and structure of Di[methoxy(ethoxy)carbonylamino-1H-benzimidazol- 5-yl] ethers

A procedure was developed for preparing di[methoxy(ethoxy)carbonylamino-1H- benzimidazol-5-yl] ethers by the reaction of methyl or ethyl chloroformate with sodium cyanamide, followed by the reaction of the resulting methyl or ethyl cyanocarbamate with 4-(3,4-diaminophenoxy)-1,2-phenylenediamine in acidic solution. 2005 Pleiades Publishing, Inc.

Synthesis and Anthelmintic Activity of 2-Substituted 5(6)-(5-Benzimidazolyloxy)- and 5(6)-Aryloxybenzimidazoles

A number of diaryl oxides (12-17 and 22-35) and 2,2'-disubstituted-5,5'-dibenzimidazolyl oxides (18-21) have been synthesized starting from 4-nitrophenol and 4-acetaminophenol respectively.All the compounds have been evaluated for their anthelmintic activity against Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis and Hymenolepsis nana in rats and Syphacia obvelata in mice.The results show that compounds 18, 19 and 33 remove 100percent of A. ceylanicum and H. nana at a single oral dose of 12.5-250 mg/kg.Compound 18 is also effective against N. brasiliensis in rats and S. obvelata in mice.