4719-73-7Relevant academic research and scientific papers
Rational Design and Synthesis of 1-(Arylideneamino)-4-aryl-1H-imidazole-2-amine Derivatives as Antiplatelet Agents
Amidi, Salimeh,Esfahanizadeh, Marjan,Tabib, Kimia,Soleimani, Zohreh,Kobarfard, Farzad
, p. 962 - 971 (2017/06/27)
Based on previous studies indicating the pharmacophoric role of a hydrazone group and azole rings for antiplatelet aggregation activity, a few series of compounds with both hydrazone and an azole (imidazole) ring in their structures were synthesized, and their platelet aggregation inhibitory effects were evaluated. Two of these 1-(arylideneamino)-4-aryl-1H-imidazole-2-amine derivatives, compounds 4 a [(E)-1-(benzylideneamino)-4-phenyl-1H-imidazol-2-amine] and 4 p [(E)-4-phenyl-1-((thiophen-2-ylmethylene)amino)-1H-imidazol-2-amine], exhibited IC50 values similar to that of acetylsalicylic acid against collagen as a platelet aggregation inducer. Structural comparison of the synthesized compounds revealed that those with a para-substituted phenyl ring on the imidazole were among the most active compounds against platelet aggregation induced by arachidonic acid (AA), and the presence of a thiophene ring in these compounds maximized their antiplatelet activity.
Synthesis of aryl-hydrazones via ultrasound irradiation in aqueous medium
Leite, Ana Cristina Lima,Moreira, Diogo Rodrigo de M.,Coelho, Lucas Cunha Duarte,de Menezes, Frederico Duarte,Brondani, Dalci José
, p. 1538 - 1541 (2008/09/19)
The synthesis of aryl-hydrazones from aromatic aldehydes/ketones and hydrazides (semicarbazide, thiosemicarbazide and aminoguanidine) is described using aqueous medium (acid conditions) under ultrasound irradiation with short reaction times (20-30 min), t
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle
Porcal, Williams,Hernandez, Paola,Boiani, Lucia,Boiani, Mariana,Ferreira, Ana,Chidichimo, Agustina,Cazzulo, Juan J.,Olea-Azar, Claudio,Gonzalez, Mercedes,Cerecetto, Hugo
, p. 6995 - 7004 (2008/12/22)
Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed compounds was successfully synthesized and biologically evaluated displaying remarkable in
