4719-73-7Relevant academic research and scientific papers
Rational Design and Synthesis of 1-(Arylideneamino)-4-aryl-1H-imidazole-2-amine Derivatives as Antiplatelet Agents
Amidi, Salimeh,Esfahanizadeh, Marjan,Tabib, Kimia,Soleimani, Zohreh,Kobarfard, Farzad
, p. 962 - 971 (2017/06/27)
Based on previous studies indicating the pharmacophoric role of a hydrazone group and azole rings for antiplatelet aggregation activity, a few series of compounds with both hydrazone and an azole (imidazole) ring in their structures were synthesized, and their platelet aggregation inhibitory effects were evaluated. Two of these 1-(arylideneamino)-4-aryl-1H-imidazole-2-amine derivatives, compounds 4 a [(E)-1-(benzylideneamino)-4-phenyl-1H-imidazol-2-amine] and 4 p [(E)-4-phenyl-1-((thiophen-2-ylmethylene)amino)-1H-imidazol-2-amine], exhibited IC50 values similar to that of acetylsalicylic acid against collagen as a platelet aggregation inducer. Structural comparison of the synthesized compounds revealed that those with a para-substituted phenyl ring on the imidazole were among the most active compounds against platelet aggregation induced by arachidonic acid (AA), and the presence of a thiophene ring in these compounds maximized their antiplatelet activity.
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle
Porcal, Williams,Hernandez, Paola,Boiani, Lucia,Boiani, Mariana,Ferreira, Ana,Chidichimo, Agustina,Cazzulo, Juan J.,Olea-Azar, Claudio,Gonzalez, Mercedes,Cerecetto, Hugo
, p. 6995 - 7004 (2008/12/22)
Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed compounds was successfully synthesized and biologically evaluated displaying remarkable in
Synthesis of aryl-hydrazones via ultrasound irradiation in aqueous medium
Leite, Ana Cristina Lima,Moreira, Diogo Rodrigo de M.,Coelho, Lucas Cunha Duarte,de Menezes, Frederico Duarte,Brondani, Dalci José
, p. 1538 - 1541 (2008/09/19)
The synthesis of aryl-hydrazones from aromatic aldehydes/ketones and hydrazides (semicarbazide, thiosemicarbazide and aminoguanidine) is described using aqueous medium (acid conditions) under ultrasound irradiation with short reaction times (20-30 min), t
