79-17-4

Usage

Uses

Used in Pharmaceutical Industry:
Pimagedine is used as a pharmaceutical compound for its ability to act as a derivative of hydrazine, guanidine, or formamide. Its unique structure allows it to be utilized in the development of drugs targeting specific conditions or diseases.
Used in Chemical Research:
In the field of chemical research, pimagedine is used as a one-carbon compound for studying its properties and potential reactions with other compounds. This can lead to the discovery of new chemical compounds and applications.
Used in Material Science:
Pimagedine's unique structure also makes it a candidate for use in material science, where it can be explored for its potential to create new materials or improve existing ones. Its ability to act as a derivative of hydrazine, guanidine, or formamide may contribute to the development of advanced materials with specific properties.
Overall, pimagedine's versatility and unique structure make it a valuable compound with potential applications in various industries, including pharmaceuticals, chemical research, and material science.

Enzyme inhibitor

This substituted hydrazine (FWhydrochloride = 110.55 g/mol; CAS 79-17-4), also named pimagedine, is a strong inhibitor of diamine oxidases as well as nitric oxide synthase. Note that aminoguanidine also inhibits the formation of advanced glycosylation end-products, reportedly by reacting with and trapping Amadori rearrangement-derived fragmentation products in solution. In view of this property, aminoguanidine has often been used to treat complications associated with chronic diabetes. Target(s): amine oxidase (copper-containing), or diamine oxidase; methylamine dehydrogenase; tryptophan tryptophylquinone enzymes; nitric-oxide synthase; b-fructofuranosidase, or invertase; monoamine oxidase, or amine oxidase; histidine decarboxylase; aldose reductase; catalase; formation of advanced glycosylation end products; adenosylmethionine decarboxylase; arginine deaminase; arginine kinase; aspartate aminotransferase; histamine N-methyltransferase.

InChI:InChI=1/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5)

Upstream product

• 420-04-2 CYANAMID 
• 674-81-7 nitrosoguanidine 
• 556-88-7 nitroguanidine 
• 14527-26-5 2-methylisothiourea sulphate 
• 4353-48-4 -guanylhydrazon 
• 4362-82-7 Pinakolon-guanylhydrazon 
• 4364-72-1 N-<1-Methylpropylidenamino>-guanidin 
• 4364-76-5 2-cyclopentylidene-1-hydrazinecarboximidamide 
• 4364-74-3 2-cyclohexylidene-1-hydrazinecarboximidamide 
• 4362-88-3 2-(1-methylethylidene)hydrazinecarboximidamide 
• 60329-03-5 guanabenz 
• 136440-59-0 (Z)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat 
• 539-57-1 4-(1⁽²⁾H-tetrazol-5-yl)-tetraz-3-ene-1-carboximidic acid amide 
• 7664-93-9 sulfuric acid 

Downstream Products

• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 109942-86-1 (4-formyl-benzylidenamino)-guanidine; nitrate 
• 126937-28-8 (4-acetylamino-benzylidenamino)-guanidine 
• 37419-88-8 N-(5-phenyl-1H-[1,2,4]triazol-3-yl)-benzamide 
• 3679-92-3 N-(benzamido)-guanidine 
• 5373-68-2 5-amino-4-phenyl-2,4-dihydro-[1,2,4]triazolidine-3-thione 
• 86044-63-5 vanillylidenamino-guanidine 
• 4362-89-4 1-phenyl-ethanone carbamimidoylhydrazone 
• 42452-51-7 (E)-2-(2-methoxybenzylidene)hydrazine-1-carboximidamide 
• 6237-77-0 Glyoxylsaeure-guanylhydrazon 
• 5382-85-4 trans-cinnamylidenamino-guanidine 
• 27277-03-8 5-amino-3-hydroxymethyl-1H-1,2,4-triazole 
• 113038-69-0 2,2'-butanediyldioxy-di-benzaldehyde bis-carbamimidoylhydrazone 
• 118837-11-9 3,3'-dimethoxy-4,4'-pentanediyldioxy-di-benzaldehyde bis-carbamimidoylhydrazone 

Relevant academic research and scientific papers

Sensitive Analysis of Nitroguanidine in Aqueous and Soil Matrices by LC-MS

Nitroguanidine, a widely used nitramine explosive, is an environmental contaminant that is refractory, persistent, highly mobile in soils and aquifers, and yet under-researched. Nitroguanidine determination in water and soil poses an analytical challenge due its high hydrophilicity, low volatility, charge neutrality over a wide pH range, and low proton affinity which results in low electrospray interface (ESI)-MS sensitivity. A sensitive method for the determination of nitroguanidine in aqueous and soil matrices was developed. The method is based on reduction by zinc in acidic solution, hydrophobization by derivatization, preconcentration on C18 cartridge, and LC-MS quantification. The demonstrated limit of detection (LOD) reaches 5 ng/L and 22 ng/g in water and soil, respectively. Analysis of a contaminated site demonstrates that it is possible to map a contamination plume that extends over 1 km from the source of the contamination.

Synthesis, Antileishmanial Activity and In Silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes

Background: Leishmaniasis is a worldwide health problem, highly endemic in developing countries. Among the four main clinical forms of the disease, visceral leishmaniasis is the most se-vere, fatal in 95% of cases. The undesired side-effects from first-li

Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors

Herein we report a microscale parallel synthetic approach allowing for rapid access to libraries of N-acylated aminotriazoles and screening of their inhibitory activity against factor XIIa (FXIIa) and thrombin, which are targets for antithrombotic drugs. This approach, in combination with post-screening structure optimization, yielded a potent 7 nM inhibitor of FXIIa and a 25 nM thrombin inhibitor; both compounds showed no inhibition of the other tested serine proteases. Selected N-acylated aminotriazoles exhibited anticoagulant properties in vitro influencing the intrinsic blood coagulation pathway, but not extrinsic coagulation. Mechanistic studies of FXIIa inhibition suggested that synthesized N-acylated aminotriazoles are covalent inhibitors of FXIIa. These synthesized compounds may serve as a promising starting point for the development of novel antithrombotic drugs.

Synthesis of 5 - amino tetrazole method

Synthesis of 5 - amino tetrazole method, in order to hydrazine hydrate, lime nitrogen, sodium nitrite, inorganic acid and inorganic base as the obtained 5 - amino tetrazole. The method through the metathesis reaction, addition reaction and diazo isomerization reaction of the cyano lead lime nitrogen into the aminoguanidine, then generating aminoguandine isomerization reaction to synthesize 5 - amino tetrazole. The invention compared with the traditional method, has the following advantages: (1) price cheap raw materials as the starting raw material, synthetic product is obtained; (2) simplified 5 - amino tetrazole operation process, reduce the reaction solvent types and process the complexity of the operation, reduces the cost of material and production cost, reduces the 5 - amino tetrazole synthesis cost of, improve the market competitiveness of the product. It has high efficiency, high yield, low cost, easy operation and the like.

Glycation Cross-link Breakers to Increase Resistance to Enzymatic Degradation

The present invention relates to a method to treat a grafts, implant, scaffold, and constructs, including allografts, xenografts, autografts, and prosthetics comprising collagen, with an inhibitor of collagen cross-links and/or advanced glycation endproducts (AGE), in order to alleviate the mechanical weakness induced by the cross-links The invention also provides for kits for use in the operating theater during autograft, allograft or xenograft procedures, or for preparing allograft, xenografts or prosthetics that have not been already treated prior to packaging. The kit comprises a first agent or agents that inhibit collagen cross-links and/or advanced glycation endproducts, instructions for use, optionally a wash or rinse agent, and a device for containing the graft and first agent.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

Dinitropyrazolopyrazole-amine salts useful in gun propellants

Dinitropyrazolopyrazole-amine salts are used as burn modifier ingredients in gun propellant compositions.

Low molecular weight bicyclic thrombin inhibitors

This invention relates to the discovery of heterocyclic competitive inhibitors of the enzyme thrombin, their preparation, and pharmaceutical compositions thereof. As well, this invention relates to the use of such compounds and compositions in vitro as anticoagulants and in vivo as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction. Moreover, these compounds and compositions have therapeutic utility for the prevention and treatment of coagulopathies associated with coronary bypass operations as well as restenotic events following transluminal angioplasty.

Antiarrhythmic active amidinohydrazones of substituted benzophenones. Part 5: Investigations on the stability of (Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate in solution

The aqueous solution of the title compound can be used for injection for one year if it is stored at room temperature and under light protection. Under these conditions 8% of the E-isomer are produced. The reaction is reversible at day light. Red coloured products of decomposition are formed by long lasting influence of light. At higher temperatures or at sterilisation several products of decomposition are formed which structure is elucidated. For these decomposition a scheme is proposed.