471923-84-9

Upstream product

• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 197520-87-9 (R)-ethyl 6-(benzyloxy)-5-hydroxyhex-2-ynoate 
• 389123-24-4 (Z)-(R)-6-Benzyloxy-3-methyl-hex-2-ene-1,5-diol 
• 389123-23-3 2-[(2S,6R)-6-((E)-2-Bromo-propenyl)-4-methylene-tetrahydro-pyran-2-yl]-ethanol 
• 389123-38-0 (Z)-(R)-6-Benzyloxy-5-hydroxy-3-methyl-hex-2-enoic acid ethyl ester 
• 389123-41-5 (Z)-(R)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal 
• 389123-40-4 (Z)-(R)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-en-1-ol 
• 389123-36-8 5-{2-[(2S,6R)-6-((E)-2-Bromo-propenyl)-4-methylene-tetrahydro-pyran-2-yl]-ethylsulfanyl}-1-phenyl-1H-tetrazole 
• 389123-37-9 5-{2-[(2S,6R)-6-((E)-2-Bromo-propenyl)-4-methylene-tetrahydro-pyran-2-yl]-ethanesulfonyl}-1-phenyl-1H-tetrazole 
• 389123-39-1 [(Z)-(R)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enyloxymethyl]-benzene 
• 389123-22-2 (2R,6R)-2-((E)-2-Bromo-propenyl)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-4-one 
• 389123-35-7 {2-[(2S,6R)-6-((E)-2-Bromo-propenyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane 
• 389123-45-9 (2R,6R)-2-[(2E,6Z)-(R)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-octa-2,6-dienyl]-6-((E)-2-bromo-propenyl)-4-methylene-tetrahydro-pyran 
• 471923-80-5 (diethoxy-phosphoryl)-acetic acid 4-{6-[4,8-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-octa-2,6-dienyl]-4-methylene-tetrahydro-pyran-2-yl}-1-[2-(3,4-dimethoxy-benzyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-3-methyl-but-3-enyl ester 

Downstream Products

• 471923-85-0 [[13-(tert-butyl-dimethyl-silanyloxy)-3,11-dimethyl-19-methylene-7-oxo-6,21-dioxa-bicyclo[15.3.1]heneicosa-2,8,10,14-tetraen-5-yl]-(4-methoxy-benzyloxy)-methyl]-hexa-2,4-dienoyl-carbamic acid 2-trimethylsilanyl-ethyl ester 

Relevant academic research and scientific papers

Total syntheses of (+)-zampanolide and (+)-dactylolide exploiting a unified strategy

The first total syntheses of (+)-zampanolide (1) and (+)-dactylolide (2), members of a new class of tumor cell growth inhibitory macrolides, have been achieved. Key features of the unified synthetic scheme included the stereocontrolled construction of the cis-2,6-disubstituted tetrahydropyran via a modified Petasis-Ferrier rearrangement, a highly convergent assembly of the macrocyclic domain, and, in the case of zampanolide, a Curtius rearrangement/acylation tactic to install the N-acyl hemiaminal. The complete relative and absolute stereochemistries for both (+)-zampanolide and (+)-dactylolide were also assigned, albeit tentatively in the case of (+)-zampanolide (1).