471925-07-2

Basic information

• Product Name: 3,4-dihydro-1-(4-fluorophenyl)-1H-2-benzopyran
• Synonyms: 3,4-dihydro-1-(4-fluorophenyl)-1H-2-benzopyran
• CAS NO: 471925-07-2
• Molecular Weight: 228.266
• Mol File: 471925-07-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3,4-dihydro-1-(4-fluorophenyl)-1H-2-benzopyran(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydro-1-(4-fluorophenyl)-1H-2-benzopyran(471925-07-2)
• EPA Substance Registry System: 3,4-dihydro-1-(4-fluorophenyl)-1H-2-benzopyran(471925-07-2)

Safety Data

• Hazardous Substances Data: 471925-07-2(Hazardous Substances Data)

Upstream product

• 50683-32-4 1-Bromoisochromane 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 493-05-0 isochromane 
• 352-13-6 4-flourophenylmagnesium bromide 
• 34818-49-0 1-methoxyisochromane 

Relevant articles and documents

Transition-Metal-Free Cross-Coupling of Indium Organometallics with Chromene and Isochroman Acetals Mediated by BF3·OEt2

A transition-metal-free coupling of triorganoindium reagents with benzopyranyl acetals mediated by a Lewis acid has been developed. The reaction of R3In with chromene and isochroman acetals in the presence of BF3·OEt2 afforded 2-substituted chromenes and 1-substituted isochromans, respectively, in good yields. The reactions proceed with a variety of triorganoindium reagents (aryl, heteroaryl, alkynyl, alkenyl, alkyl) using only 50 mol % of the organometallic, thus demonstrating the efficiency of these species. Preliminary mechanistic studies indicate the formation of an oxocarbenium ion intermediate in the presence of the Lewis acid.

Organocatalytic approach for C(sp3)-H bond arylation, alkylation, and amidation of isochromans under facile conditions

A new catalytic approach for the synthesis of isochroman derivatives via direct C(sp3)-H bond arylation is described. The oxidation reaction with [bis(trifluoroacetoxy)iodo]benzene facilitates the regeneration of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the C(sp3)-H bond arylation of isochroman. The reaction conditions can also be used for alkyl Grignard reagents and amides to afford the corresponding isochroman derivatives.

1-Aryl-isochromanes related to floutexin (in German)

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