4682-70-6

Basic information

• Product Name: 19-nordeoxycorticosterone
• Synonyms: 19-nordeoxycorticosterone
• CAS NO: 4682-70-6
• Molecular Formula: C20H28O3
• Molecular Weight: 316.438
• Mol File: 4682-70-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 490.4°Cat760mmHg
• Flash Point: 264.5°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 1.13E-11mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 19-nordeoxycorticosterone(CAS DataBase Reference)
• NIST Chemistry Reference: 19-nordeoxycorticosterone(4682-70-6)
• EPA Substance Registry System: 19-nordeoxycorticosterone(4682-70-6)

Safety Data

• Hazardous Substances Data: 4682-70-6(Hazardous Substances Data)

Usage

Uses

Corticosterone derivative/degradation product. 19-Nordeoxycorticosterone can be used in biological study of correlation between pregnanesteroid conformation, renal mineralocorticoid receptor affinity, and anti-natriuretic effect.

InChI:InChI=1/C20H28O3/c1-20-9-8-15-14-5-3-13(22)10-12(14)2-4-16(15)17(20)6-7-18(20)19(23)11-21/h10,14-18,21H,2-9,11H2,1H3/t14-,15+,16+,17-,18+,20-/m0/s1

Upstream product

• 472-54-8 19-norprogesterone 
• 4682-71-7 21-acetoxy-19-nor-pregn-4-ene-3,20-dione 
• 88378-35-2 19-oxo-11-deoxycorticosterone acetate 
• 135399-04-1 (+)-11-deoxy-19-corticosterone benzoate 
• 74824-66-1 19-nordeoxycorticosterone 3,20-bis(1,3-propanedithiyl acetal) 
• 14667-20-0 21-acetoxypregn-4-ene-3,20-dione-19-oic acid 
• 65078-08-2 (Z)-3,20-dimethoxy-21-hydroxy-19-norpregna-1,3,5⁽¹⁰⁾,17⁽²⁰⁾-tetraene 
• 2863-88-9 3-ethoxy-19-nor-3,5-androstadiene-17-one 
• 80134-11-8 [(8R,9S,10R,13S,14S)-3-Ethoxy-13-methyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-formylamino-acetic acid ethyl ester 
• 1778-02-5 Pregnenolone acetate 
• 2723-07-1 5-Bromo-6β-hydroxy-20-oxo-5α-pregnan-3β-yl acetate 
• 6901-40-2 19,21-dihydroxypregn-4-ene-3,20-dione 21-acetate 
• 41767-48-0 5-Bromo-20-oxo-6β,19-epoxy-5α-pregnan-3β-yl acetate 
• 90075-56-2 5-bromo-3β,21-dihydroxy-6β,19-epoxy-5α-pregnan-20-one 21-acetate 

Relevant articles and documents

Synthesis of 19-nordeoxycorticosterone 3-(O-carboxymethyl)-oxime

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Synthesis of 19-norprogesterone and 19-nordeoxycorticosterone

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A facile and enantioselective total synthesis of (+)-19-nordeoxycorticosterone

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Process for the synthesis of the hydroxyacetyl side-chain of steroids of the pregnane type, novel 21-hydroxy-20-oxo-17α-pregnane compounds and pharmaceutical preparations containing them

The present invention relates to a novel general process for synthesizing a α- or β-oriented hydroxyacetyl side chain of steroids of the pregnane type, which comprises treating a corresponding steroid carbaldehyde in succession with formaldehyde dimethylmercaptal-S-oxide in the form of an alkali metal salt thereof, and with a strongly acid hydrolysing agent.Preferred final products are compounds of the formula STR1 wherein n is 1 or 2, R 2 represents methyl or difluoromethyl, and R 1 represents hydroxymethyl, methoxymethyl, acetoxymethyl or hydrogen, and, if n is 2 and/or R 2 is difluoromethyl, R 1 also represents methyl. These compounds act as agonists or antagonists of natural steroid hormones. The antigestagenic 19,21-dihydroxy-17α-pregn-4-ene-3,20-dione and its 6,7-dehydro derivatives and diacetates are of particular interest.