47223-94-9

Basic information

• Product Name: 1H-Indole, 2-(diphenylmethyl)-
• CAS NO: 47223-94-9
• Molecular Formula: C21H17N
• Molecular Weight: 283.373
• Mol File: 47223-94-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2-(diphenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2-(diphenylmethyl)-(47223-94-9)
• EPA Substance Registry System: 1H-Indole, 2-(diphenylmethyl)-(47223-94-9)

Safety Data

• Hazardous Substances Data: 47223-94-9(Hazardous Substances Data)

Usage

General Description

1H-Indole, 2-(diphenylmethyl)- is a chemical compound with the molecular formula C23H19N. It is an indole derivative that contains a diphenylmethyl group attached to the second carbon of the indole ring. 1H-Indole, 2-(diphenylmethyl)- is often used as a building block for the synthesis of various pharmaceuticals and other organic compounds. It has potential applications in medical research and drug development due to its unique chemical structure and biological activity. Additionally, it may have potential uses in the development of new materials and chemicals for various industrial applications.

Upstream product

• 98-80-6 phenylboronic acid 
• 742078-49-5 N-[2-(tert-butyldimethylsiloxymethyl)phenyl]-4-methylphenylsulfonamide 
• 90312-02-0 N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 86531-02-4 1H-indol-1-yl benzoate 
• 3289-82-5 1-hydroxyindole 
• 134792-59-9 1-(t-butyldimethylsilyloxy)indole 
• 54698-11-2 1-methoxyindole 
• 119-61-9 benzophenone 
• 144219-54-5 1-methoxymethoxyindole 
• 496-15-1 1-indoline 
• 655230-11-8 dithiocarbonic acid O-ethyl ester S-(2-triphenylphosphoranylideneamino)benzyl ester 
• 655229-95-1 dithiocarbonic acid O-ethyl ester S-(2-azidobenzyl) ester 
• 525-06-4 diphenyl ketene 

Relevant articles and documents

2,3-disubstituted indoline compound as well as preparation method and application thereof

The invention discloses a preparation method of a 2,3-disubstituted indoline compound, as well as a preparation method and application thereof. A tert-butyl sulfonyl (Bus) protected imine-alkyne aminecompound shown as a formula I and aryl boronic acid are used as raw materials; according to the preparation method, high-regioselectivity arylation cyclization is realized under mild reaction conditions in the presence of a cheap copper catalyst, and various 2,3-disubstituted indoline compounds are conveniently prepared at medium to excellent yield, and have a wide substrate application range andgroup tolerance. The 2,3-disubstituted indoline compound can be conveniently made into various useful 2-benzyl-1H-indole compounds and indolyl methanol compounds.

Lithiation of 1-alkoxyindole derivatives

Lithiation of 1-alkoxyindoles, 3-dimethylaminomethyl- and 3-dimethylaminoethyl-1-methoxyindole occurred regioselectively at the 2-position. The introduction of a sterically bulky group into the 2-position of 3-dimethylaminomethyl-1-methoxyindoles directed the lithiation to the 4-position.

First radical addition onto ketenimines: A novel synthesis of indoles

A novel radical-mediated synthesis of 2-alkyl indoles is described. The method is a nonchain process based on the intramolecular addition of benzylic radicals onto the central carbon atom of a ketenimine function, resulting in a 5-exo-dig cyclization.