47223-94-9

Usage

General Description

1H-Indole, 2-(diphenylmethyl)- is a chemical compound with the molecular formula C23H19N. It is an indole derivative that contains a diphenylmethyl group attached to the second carbon of the indole ring. 1H-Indole, 2-(diphenylmethyl)- is often used as a building block for the synthesis of various pharmaceuticals and other organic compounds. It has potential applications in medical research and drug development due to its unique chemical structure and biological activity. Additionally, it may have potential uses in the development of new materials and chemicals for various industrial applications.

Upstream product

• 144219-59-0 α,α-diphenyl-1-(methoxymethoxy)indole-2-methanol 
• 496-15-1 1-indoline 
• 119-61-9 benzophenone 
• 134792-59-9 1-(t-butyldimethylsilyloxy)indole 
• 3289-82-5 1-hydroxyindole 
• 86531-02-4 1H-indol-1-yl benzoate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 90312-02-0 N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide 
• 742078-49-5 N-[2-(tert-butyldimethylsiloxymethyl)phenyl]-4-methylphenylsulfonamide 
• 98-80-6 phenylboronic acid 
• 54698-11-2 1-methoxyindole 
• 144219-54-5 1-methoxymethoxyindole 
• 655230-11-8 dithiocarbonic acid O-ethyl ester S-(2-triphenylphosphoranylideneamino)benzyl ester 
• 655229-95-1 dithiocarbonic acid O-ethyl ester S-(2-azidobenzyl) ester 

Relevant academic research and scientific papers

2,3-disubstituted indoline compound as well as preparation method and application thereof

The invention discloses a preparation method of a 2,3-disubstituted indoline compound, as well as a preparation method and application thereof. A tert-butyl sulfonyl (Bus) protected imine-alkyne aminecompound shown as a formula I and aryl boronic acid are used as raw materials; according to the preparation method, high-regioselectivity arylation cyclization is realized under mild reaction conditions in the presence of a cheap copper catalyst, and various 2,3-disubstituted indoline compounds are conveniently prepared at medium to excellent yield, and have a wide substrate application range andgroup tolerance. The 2,3-disubstituted indoline compound can be conveniently made into various useful 2-benzyl-1H-indole compounds and indolyl methanol compounds.

Copper-catalyzed tandemcis-carbometallation/cyclization of imine-ynamides with arylboronic acids

An efficient copper-catalyzed tandem regioselectivecis-carbometallation/cyclization of imine-ynamides with arylboronic acids has been developed. This method leads to a facile and practical synthesis of valuable 2,3-disubstituted indolines in moderate to e

Lithiation of 1-alkoxyindole derivatives

Lithiation of 1-alkoxyindoles, 3-dimethylaminomethyl- and 3-dimethylaminoethyl-1-methoxyindole occurred regioselectively at the 2-position. The introduction of a sterically bulky group into the 2-position of 3-dimethylaminomethyl-1-methoxyindoles directed the lithiation to the 4-position.

Intramolecular addition of benzylic radicals onto ketenimines. Synthesis of 2-alkylindoles

The inter- and intramolecular addition of free radicals onto ketenimines is studied. All the attempts to add intermolecularly several silicon, oxygen or carbon centered radicals to N-(4-methylphenyl)-C,C-diphenyl ketenimine were unsuccessful. In contrast, the intramolecular addition of benzylic radicals, generated from xanthates, onto the central carbon of a ketenimine function with its N atom linked to the ortho position of the aromatic ring occurred under a variety of reaction conditions. These intramolecular cyclizations provide a novel radical-mediated synthesis of 2-alkylindoles.

First radical addition onto ketenimines: A novel synthesis of indoles

A novel radical-mediated synthesis of 2-alkyl indoles is described. The method is a nonchain process based on the intramolecular addition of benzylic radicals onto the central carbon atom of a ketenimine function, resulting in a 5-exo-dig cyclization.

A REGIOSELECTIVE LITHIATION OF 1-METHOXYMETHOXYINDOLE AT THE 2-POSITION AND ITS APPLICATION FOR THE SYNTHESIS OF 2-SUBSTITUTED INDOLES

A regioselective lithiation of 1-methoxymethoxyindole at the 2-position was achieved with n-BuLi at 0 deg C.Subsequent treatment with electrophiles afforded 2-substituted 1-methoxymethoxyindoles, which were readily converted to 2-substituted indoles.

PREPARATION OF 1-HYDROXYINDOLE DERIVATIVES AND A NEW ROUTE TO 2-SUBSTITUTED INDOLES

An easy handling method of 1-hydroxyindole is developed.Based on the method, preparation and reaction of 1-hydroxyindole derivatives are investigated.A new regioselective lithiation of 1-methoxyindole and its application for the synthesis of 2-substituted indoles are also reported.