90312-02-0

Basic information

• Product Name: N-(2-HYDROXYMETHYL-PHENYL)-4-METHYL-BENZENESULFONAMIDE
• Synonyms: N-(2-HYDROXYMETHYL-PHENYL)-4-METHYL-BENZENESULFONAMIDE
• CAS NO: 90312-02-0
• Molecular Formula: C₁₄H₁₅NO₃S
• Molecular Weight: 277.34
• Mol File: 90312-02-0.mol
• Article Data: 66

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-HYDROXYMETHYL-PHENYL)-4-METHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-HYDROXYMETHYL-PHENYL)-4-METHYL-BENZENESULFONAMIDE(90312-02-0)
• EPA Substance Registry System: N-(2-HYDROXYMETHYL-PHENYL)-4-METHYL-BENZENESULFONAMIDE(90312-02-0)

Safety Data

• Hazardous Substances Data: 90312-02-0(Hazardous Substances Data)

Upstream product

• 529-23-7 o-aminobenzaldehyde 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 612-25-9 2-Nitrobenzyl alcohol 
• 98-59-9 p-toluenesulfonyl chloride 
• 552-89-6 2-nitro-benzaldehyde 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 118-92-3 anthranilic acid 
• 134-20-3 2-carbomethoxyaniline 
• 5344-90-1 2-Aminobenzyl alcohol 
• 50998-74-8 methyl N-tosylanthranilate 

Downstream Products

• 1315477-55-4 N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide 
• 1448808-99-8 2-(iodomethylene)-1-tosylindolin-3-one 
• 1269261-63-3 2-(bromomethyl)-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline 
• 1096365-37-5 1-tosyl-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepine 
• 1210801-46-9 N-(2-(bromomethyl)phenyl)-4-methyl-benzenesulfonamide 
• 1198161-52-2 (S)-3,4-dibenzyl-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine 
• 1198161-50-0 C₃₀H₃₂N₂O₃S 
• 1198161-51-1 C₃₀H₃₂N₂O₃S 
• 1198161-58-8 (S)-4-benzyl-1,5-ditosyl-1,2,3,4,5,6-hexahydrobenzo[b][1,5]diazocine 
• 1198161-68-0 C₃₁H₃₄N₂O₅S₂ 
• 1198161-56-6 C₃₁H₃₄N₂O₅S₂ 
• 932725-44-5 C₃₀H₃₂N₂O₅S₂ 
• 1198161-67-9 C₃₀H₃₂N₂O₅S₂ 
• 932725-46-7 (S)-3-benzyl-1,4-bis-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine 

Relevant articles and documents

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds and two rings from readily accessible starting materials in a single operation. Furthermore, this methodology can also be utilized to construct chromeno[4,3-c]pyridines and benzo[c][2,6]naphthyridines in moderate yields.

Copper-Catalyzed (4+1) Cascade Annulation of Terminal Alkynes with 2-(Tosylmethyl)anilines: Synthesis of 2,3-Disubstituted Indoles

A novel strategy based on Cu-catalyzed (4+1) cascade annulation of terminal alkynes as one-carbon synthons with 2-(tosylmethyl)anilines has been developed for the expeditious synthesis of 2,3-disubstituted indoles, in which in situ generations of aza-o-quinone methides and alkynyl-copper(I) species are involved. This annulation provides an effective method for the assembly of synthetically and structurally interesting 2,3-disubstituted indoles.

Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines

In the past decades, significant advances have been made on radical Smiles rearrangement. However, the eventually formed radical intermediates in these reactions are limited to the amidyl radical, except for the few examples initiated by a N-centered radical. Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chemistry can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation. Moreover, such an ynamide Smiles rearrangement initiated by intermolecular photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates.