4726-30-1

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 95-50-1 1,2-dichloro-benzene 
• 95-16-9 1,3-Benzothiazole 
• 615-41-8 2-iodochlorobenzene 
• 19284-81-2 2-(2-nitro)phenylthiophenylamine 
• 33253-01-9 (2-chloro-phenyl)-(2-nitro-phenyl)-sulfane 

Downstream Products

• 101780-86-3 N,N-diethyl-N'-[2-(2-chloro-phenylsulfanyl)-phenyl]-ethylenediamine 

Relevant academic research and scientific papers

Synthesis of phenothiazines via ligand-free CuI-catalyzed cascade C-S and C-N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols

A ligand-free CuI-catalyzed cascade C-S and C-N cross coupling of (hetero)aryl ortho-dihalides and ortho-aminobenzenethiols has been developed, and various phenothiazines were synthesized with excellent regioselectivity. A possible mechanism is proposed for the cascade coupling.

Unexpectedly ligand-free copper-catalyzed C-S cross-coupling of benzothiazole with aryl iodides in aqueous solution

A novel synthetic protocol for 2-aminophenyl sulfide derivatives via the reactions of benzothiazole with aryl iodides was reported for the first time. The reactions were catalyzed by CuCl with tetrabutylammonium hydroxide as the base and water as the solvent without ligand at 50°C or room temperature. A variety of aryl iodides underwent the C-S cross-coupling reaction with benzothiazole to afford smoothly the corresponding products in excellent yield.