4728-82-9 Usage
Identification
▼▲
CAS.No.:?
4728-82-9?
FL.No.:?
9.482
FEMA.No.:?
2023
NAS.No.:?
2023
CoE.No.:?
2070
EINECS.No.:?
225-230-0?
JECFA.No.:?
12
Description
A liquid with an intense, sweet, long-lasting fruital (pineapple, peach, apricot) aroma. It is used as a flavor enhancer, flavoring agent and adjuvant.
Regulatory Status
CoE: n/a
FDA: 21 CFR 172.515
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (1996).
Usage
Reported uses (ppm): (FEMA, 1994)
▼▲
Food Category?
Usual?
Max.?
Alcoholic beverages?
1
2
Baked goods?
41.77
57.58
Frozen dairy?
7.64
16.14
Gelatins, puddings?
11.42
17.17
Nonalcoholic beverages?
4.69
7.59
Soft candy?
30.69
37.27
Natural occurrence
Not reported found in nature.
Chemical Properties
A liquid with an intense, sweet, long-lasting fruital (pineapple, peach, apricot) aroma. It is used as a flavor enhancer,
flavoring agent and adjuvant.
Occurrence
Has apparently not been reported to occur in nature.
Preparation
By esterfication of cyclohexane, acetic acid and allyl alcohol in the presence of benzene
Taste threshold values
Taste characteristics at 15 ppm: pineapple with a sweet, ripe, fruity nuance.
Metabolism
The hydrolysis of ester linkages in foreign compounds may be catalysed by many different esterases; most of these have a low degree of substrate specificity and they are to be found in all animals and bacteria (Parke, 1968). In the rat, allyl acetate and allyl alcohol are metabolized to 3-hydroxypropylmercapturic acid, which is excreted in the urine (Clapp, Kaye & Young,
1969). In dogs, cyclohexylacetic acid was not aromatized and was probably completely oxidized in the body by β-oxidation (Bernhard, 1937; Williams, 1959).
Check Digit Verification of cas no
The CAS Registry Mumber 4728-82-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,2 and 8 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4728-82:
(6*4)+(5*7)+(4*2)+(3*8)+(2*8)+(1*2)=109
109 % 10 = 9
So 4728-82-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H18O2/c1-2-8-13-11(12)9-10-6-4-3-5-7-10/h2,10H,1,3-9H2
4728-82-9Relevant articles and documents
Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates
Alexy, Eric J.,Zhang, Haiming,Stoltz, Brian M.
supporting information, p. 10109 - 10112 (2018/08/06)
The first enantioselective palladium-catalyzed decarboxylative allylic alkylation of fully substituted acyclic enol carbonates providing linear α-quaternary ketones is reported. Investigation into the reaction revealed that the use of an electron-deficient phosphinooxazoline ligand renders the enolate geometry of the starting material inconsequential, with the same enantiomer of product obtained in the same level of selectivity regardless of the starting ratio of enolates. As a result, a general method toward acyclic all-carbon quaternary stereocenters has been developed.
