47295-77-2

Usage

Uses

Used in Scientific Research:
H-Gly-Pro-Arg-OH is used as a model compound for studying the structure and function of peptides and proteins, providing insights into their interactions and mechanisms within biological systems.
Used in Biochemical Research:
H-Gly-Pro-Arg-OH is employed as a research tool to explore the sequence-specific biological activity of peptides, potentially contributing to the understanding of their roles in physiological processes.
Used in Pharmaceutical Development:
Given its potential biological activity and role in physiological processes, H-Gly-Pro-Arg-OH may be utilized in the development of pharmaceuticals targeting specific biological pathways or conditions.
Used in Diagnostic Applications:
The peptide's specific interactions with biological molecules could be harnessed for diagnostic purposes, aiding in the detection or monitoring of certain diseases or conditions.
Used in Drug Delivery Systems:
H-Gly-Pro-Arg-OH may be explored for its potential in drug delivery, where its peptide structure could be employed to improve the targeting, bioavailability, or therapeutic efficacy of various drugs.

InChI:InChI=1/C13H24N6O4/c14-7-10(20)19-6-2-4-9(19)11(21)18-8(12(22)23)3-1-5-17-13(15)16/h8-9H,1-7,14H2,(H,18,21)(H,22,23)(H4,15,16,17)/t8-,9-/m0/s1

Upstream product

• 17011-78-8 4-Phenylazobenyzloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg 
• 41863-49-4 t-butyloxycarbonyl-glycyl-proline methyl ester 
• 14296-92-5 (S)-1-(2-(tert-butoxycarbonylamino)acetyl)pyrrolidine-2-carboxylic acid 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 13726-76-6 t-butyloxycarbonyl-L-arginine 
• 69304-16-1 H-Arg-AMC*2HCl 
• 1186293-72-0 Boc-Gly-Pro-Arg-AMC*HCl 

Relevant academic research and scientific papers

Purification and characterization of a major collagenase from Streptomyces parvulus

A major collagenase was purified about 96-fold from a crude enzyme sample of Streptomyces parvulus by chromatography on Q-Sepharose, Sephacryl S-200, and butyl-Toyopearl. The purified enzyme showed a relative molecular mass of approximately 52,000 on SDS-

A macrocyclic coumarin-containing tripeptide via CuAAC chemistry

A Cu-catalysed macrocyclisation was performed to obtain a macrocyclic coumarin-containing tripeptide for use in thrombin activity measurements.

Protease mediated drug delivery system

Lipophilic and amphiphilic therapeutic or diagnostic agents having water solubilizing groups attached thereto by bonds that can be cleaved readily by one or more of the various proteases that are active in the extracellular fluid or on the surfaces of cells in many types of malignant tissue may accumulate selectively in such malignant tissues. Protease mediated removal of the water solubilizing groups converts such drugs into lipophilic or amphiphilic forms which are more soluble in plasma membrane lipids and which therefore enter cells more readily. Since the extracellular fluid in most non-malignant tissues under normal circumstances has little such protease activity, removal of the water solubilizing groups takes place primarily within malignant tissues, with consequent preferential accumulation of the lipophilic or amphiphilic forms of the drug within malignant tissues. Certain lipophilic and amphiphilic porphyrins and chlorins may be modified by the addition of water solubilizing groups, such as alcohols, which are attached by short polypeptide chains, that are stable while in the circulation but are cleaved by proteases in malignant tissue to provide novel compounds useful for the photodynamic therapy of cancer.