47295-77-2

Basic information

• Product Name: H-Gly-Pro-Arg-OH
• Synonyms: H-Gly-Pro-Arg-OH
• CAS NO: 47295-77-2
• Molecular Formula: C13H24N6O4
• Molecular Weight: 328.36746
• Mol File: 47295-77-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.54g/cm³
• Refractive Index: 1.664
• CAS DataBase Reference: H-Gly-Pro-Arg-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-Gly-Pro-Arg-OH(47295-77-2)
• EPA Substance Registry System: H-Gly-Pro-Arg-OH(47295-77-2)

Safety Data

• Hazardous Substances Data: 47295-77-2(Hazardous Substances Data)

Usage

General Description

The chemical H-Gly-Pro-Arg-OH is a peptide consisting of four amino acids: glycine, proline, arginine, and an hydroxyl group at the C-terminus. This peptide has a molecular formula of C14H25N7O4 and a molecular weight of 347.39 g/mol. It is commonly used in biological and biochemical research as a model compound for studying the structure and function of peptides and proteins. The sequence of amino acids in H-Gly-Pro-Arg-OH is important for its specific biological activity, and it may play a role in various physiological processes in the body. Overall, H-Gly-Pro-Arg-OH is a versatile chemical with potential applications in scientific research and medicine.

InChI:InChI=1/C13H24N6O4/c14-7-10(20)19-6-2-4-9(19)11(21)18-8(12(22)23)3-1-5-17-13(15)16/h8-9H,1-7,14H2,(H,18,21)(H,22,23)(H4,15,16,17)/t8-,9-/m0/s1

Upstream product

• 17011-78-8 4-Phenylazobenyzloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg 
• 41863-49-4 t-butyloxycarbonyl-glycyl-proline methyl ester 
• 14296-92-5 (S)-1-(2-(tert-butoxycarbonylamino)acetyl)pyrrolidine-2-carboxylic acid 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 13726-76-6 t-butyloxycarbonyl-L-arginine 
• 69304-16-1 H-Arg-AMC*2HCl 
• 1186293-72-0 Boc-Gly-Pro-Arg-AMC*HCl 

Relevant articles and documents

Purification and characterization of a major collagenase from Streptomyces parvulus

A major collagenase was purified about 96-fold from a crude enzyme sample of Streptomyces parvulus by chromatography on Q-Sepharose, Sephacryl S-200, and butyl-Toyopearl. The purified enzyme showed a relative molecular mass of approximately 52,000 on SDS-

Protease mediated drug delivery system

Lipophilic and amphiphilic therapeutic or diagnostic agents having water solubilizing groups attached thereto by bonds that can be cleaved readily by one or more of the various proteases that are active in the extracellular fluid or on the surfaces of cells in many types of malignant tissue may accumulate selectively in such malignant tissues. Protease mediated removal of the water solubilizing groups converts such drugs into lipophilic or amphiphilic forms which are more soluble in plasma membrane lipids and which therefore enter cells more readily. Since the extracellular fluid in most non-malignant tissues under normal circumstances has little such protease activity, removal of the water solubilizing groups takes place primarily within malignant tissues, with consequent preferential accumulation of the lipophilic or amphiphilic forms of the drug within malignant tissues. Certain lipophilic and amphiphilic porphyrins and chlorins may be modified by the addition of water solubilizing groups, such as alcohols, which are attached by short polypeptide chains, that are stable while in the circulation but are cleaved by proteases in malignant tissue to provide novel compounds useful for the photodynamic therapy of cancer.