472956-79-9Relevant academic research and scientific papers
Baylis-Hillman reactions of N-arylidenediphenylphosphinamides with methyl vinyl ketone, methyl acrylate, and acrylonitrile
Shi, Min,Zhao, Gui-Ling
, p. 4499 - 4502 (2002)
We have found that in the Baylis-Hillman reactions of N-arylidenediphenylphosphinamides 1 with methyl vinyl ketone (MVK), methyl acrylate or acrylonitrile, the Lewis base and solvent can significantly affect the reaction rate. Using PPh3 as Lewis base in the reaction of 1 with MVK in DMF, THF or MeCN, the normal Baylis-Hillman adduct 2 was formed in very high yield. In the Baylis-Hillman reaction of 1 with methyl acrylate, the Lewis base Ph2PMe must be used in order to get a high yield of the Baylis-Hillman adduct 3. On the other hand, for the reaction of N-arylidenediphenylphosphinamides 1 with acrylonitrile, DABCO is the best Lewis base giving the corresponding Baylis-Hillman adducts 4 in high yields.
One-pot aza-Baylis-Hillman reactions of arylaldehydes and diphenylphosphinamide with methyl vinyl ketone in the presence of TiCl4, PPh3, and Et3N
Shi, Min,Zhao, Gui-Ling
, p. 9171 - 9174 (2002)
We found that one-pot, three-component, aza-Baylis-Hillman reactions of arylaldehydes, diphenylphosphinamide, and methyl vinyl ketone (MVK) can be realized in the presence of TiCl4 (0.8 equiv.), PPh3 (0.1 equiv.), and Et3N
Aza-Baylis-Hillman reactions of N-(arylmethylene) diphenylphosphinamides with activated olefins in the presence of various Lewis bases
Shi, Min,Zhao, Gui-Ling
, p. 1205 - 1219 (2007/10/03)
The aza-Baylis-Hillman reactions of N-(arylmethylene)diphenylphosphinamides with methyl vinyl ketone (MVK), methyl acrylate, acrylonitrile, ethyl vinyl ketone (EVK), phenyl vinyl ketone (PVK), phenyl acrylate, 2-cyclopenten-1-one, 2-cyclohexen-1-one have
