473259-24-4

Upstream product

• 6940-78-9 4-chlorobutyl bromide 
• 68078-10-4 1-p-phenylpiperidine-2-carbonitrile 

Downstream Products

• 473259-19-7 2-(4-cyano-butyl)-1-phenyl-piperidine-2-carbonitrile 
• 473259-21-1 7-amino-1-phenyl-1-aza-spiro[5.5]undec-7-ene-8-carbonitrile 

Relevant academic research and scientific papers

Synthesis of 1-Azaspiroundecane ring system via Thorpe-Ziegler annulation of 2-Cyano-2-(4-Cyano-Tethered) Arylpiperidines

An efficient stereocontrolled route to the spiro[5.5]undecan framework of the histrionicotoxin alkaloids, employing anodic cyanation and Thorpe-Ziegler cyclization as key steps, is described. In the process of gaining information concerning the hydrolysis of the cyanoenamine function in 8, an unexpected intramolecular Friedel-Crafts type reaction provided the aza-fluorene 10.