68078-10-4

Basic information

• Product Name: 1-Phenyl-2-cyanopiperidine
• Synonyms: 1-Phenyl-2-cyanopiperidine;1-Phenylpiperidine-2-carbonitrile;1-Phenyl-2-piperidinecarbonitrile;2-Cyano-N-phenylpiperidine
• CAS NO: 68078-10-4
• Molecular Formula: C₁₂H₁₄N₂
• Molecular Weight: 186
• Mol File: 68078-10-4.mol
• Article Data: 38

Chemical Properties

• Melting Point: 60-61℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Phenyl-2-cyanopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2-cyanopiperidine(68078-10-4)
• EPA Substance Registry System: 1-Phenyl-2-cyanopiperidine(68078-10-4)

Safety Data

• Hazardous Substances Data: 68078-10-4(Hazardous Substances Data)

Usage

General Description

1-Phenyl-2-cyanopiperidine is a type of chemical compound with the molecular formula C12H14N2. This organic compound generally appears as a solid at room temperature. It's mainly used in the field of organic synthesis. For instance, it is used in the synthesis of Fentanyl, a potent synthetic opioid that is used as a pain medication and sometimes for anesthesia. Due to its potential misuse in the production of illegal narcotics, the sale, purchase, and possession of this chemical is regulated and monitored by law enforcement agencies in some countries.

Upstream product

• 4096-20-2 N-phenyl piperidine 
• 7677-24-9 trimethylsilyl cyanide 
• 140-29-4 phenylacetonitrile 
• 613-90-1 benzoyl cyanide 
• 172876-96-9 3-oxo-1λ³-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile 
• 623-26-7 terephthalonitrile 
• 110-89-4 piperidine 
• 108-86-1 bromobenzene 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 108-90-7 chlorobenzene 
• 623-49-4 ethyl cyanoformate 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 773837-37-9 sodium cyanide 
• 143-33-9 sodium cyanide 

Downstream Products

• 473259-24-4 2-(4-chloro-butyl)-1-phenyl-piperidine-2-carbonitrile 
• 473259-27-7 2-pentyl-1-phenylpiperidine-2-carbonitrile 
• 473259-26-6 1-phenyl-2-propyl-piperidine-2-carbonitrile 
• 473259-17-5 2-methyl-1-phenyl-piperidine-2-carbonitrile 
• 473259-21-1 7-amino-1-phenyl-1-aza-spiro[5.5]undec-7-ene-8-carbonitrile 
• 473259-19-7 2-(4-cyano-butyl)-1-phenyl-piperidine-2-carbonitrile 

Relevant articles and documents

Electrochemically promoted oxidative α-cyanation of tertiary and secondary amines using cheap AIBN

The electrochemical α-cyanation of tertiary and secondary amines has been developed by using a cheap cyanide reagent, azobisisobutyronitrile (AIBN). The CN radical, generated throughn-Bu4NBr-meidated electrochemical oxidation, participates in a novel α-cyanation reaction under exogenous oxidant-free conditions.

Visible-Light-Induced α-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes

Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, has been disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in N,N-diethylethanamide in the presence of Cs2CO3 afforded α-arylated amines in good to excellent yields.

Electrochemical strategies for: N -cyanation of secondary amines and α C -cyanation of tertiary amines under transition metal-free conditions

Transition metal-free electrochemical approaches for the N-cyanation of secondary amines and the α C-cyanation of tertiary amines have been well established, with products being obtained in moderate to good yields and with good functional group tolerance under ambient conditions. The synthetic application of the protocols has been highlighted through scale-up experiments in a galvanostatic mode. Preliminary mechanistic investigation has confirmed that TBAB played a critical role in N-cyanation transformation and has indicated that the transformation might proceed via a free radical process. This journal is