473420-76-7

Upstream product

• 22441-51-6 N-1-(2-hydroxyethyl)thymine 
• 714251-15-7 bis-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-phosphinic acid methyl ester 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 473420-84-7 [bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-hydroxymethyl-phosphinic acid 2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethyl ester 

Relevant academic research and scientific papers

Bis(hydroxymethyl)phosphinic acid analogues of acyclic nucleosides; synthesis and incorporation into short DNA oligomers

Novel analogues of acyclic nucleosides based on a bis(hydroxymethyl)phosphinic acid (BHPA) backbone were obtained by condensation of the bis(4,4′-dimethoxytrityl) derivative of BHPA with N-1- or N-3-(2-hydroxyethyl)thymine in the presence of MSNT, or by an Appel reaction with N-1- or N-3-(2-aminoethyl)thymine. After selective deprotection and phosphitylation they were used as monomers for automated solid support synthesis of short oligomers by the phosphoramidite approach.