473436-52-1Relevant academic research and scientific papers
Synthesis of febrifugine derivatives and a solution to the puzzle of the structural determination of febrifugine
Takeuchi, Yasuo,Azuma, Kumiko,Oshige, Miyo,Abe, Hitoshi,Nishioka, Hiromi,Sasaki, Kenji,Harayama, Takashi
, p. 1639 - 1646 (2003)
The stereo-structure of piperidine lactone (3), a synthetic intermediate of the antimalarial agent febrifugine ((+)-1) with a piperidine ring in the trans relative configuration, was re-revised to the cis-form. We determined that isomerization to the trans-form from the cis-form occurred in the stage (6 from 5) of deprotection in Baker's synthesis.
Re-revision of the stereo structure of piperidine lactone, an intermediate in the synthesis of febrifugine.
Takeuchi, Yasuo,Azuma, Kumiko,Abe, Hitoshi,Sasaki, Kenji,Harayama, Takashi
, p. 1011 - 1012 (2007/10/03)
The stereo structure of piperidine lactone (3), an intermediate of the antimalarial agent febrifugine ((+)-1) prepared by a synthetic method, was re-revised to the cis-form from the trans-form.
