473449-32-0Relevant articles and documents
Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens
Yu, Hai,Santra, Abhishek,Li, Yanhong,McArthur, John B.,Ghosh, Tamashree,Yang, Xiaoxiao,Wang, Peng G.,Chen, Xi
supporting information, p. 4076 - 4080 (2018/06/12)
A highly efficient streamlined chemoenzymatic strategy for total synthesis of four prioritized ganglioside cancer antigens GD2, GD3, fucosyl GM1, and GM3 from commercially available lactose and phytosphingosine is demonstrated. Lactosyl sphingosine (LacβS
Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy
Wang, Ying-Hsin,Yeh, Hsien-Wei,Wang, Hsiao-Wen,Yu, Chia-Chun,Guh, Jih-Hwa,Liu, Der-Zen,Liang, Pi-Hui
, p. 118 - 135 (2013/07/27)
Naturally occurring spirostanol saponins bear a chacotriose, α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)] -β-d-glucopyranose residue as the oligosaccharide moiety which is believed to be important for biological activity. Herein the development of a concise, combinatorial method for the synthesis of two series of glycan variants at the 2′ and/or 4′ positions of chacotriose is described and the structure-activity relationships of the glycone part at 3-OH of chlorogenin investigated. These compounds were found to be weakly-cytotoxic toward leukemia cell lines CCRF and HL-20, indicating that the chacotriose moiety is important for anticancer activity.
Synthesis of LD-Hepp and KDO containing di- and tetrasaccharide derivatives of Neisseria meningitidis inner-core region via iodonium ion promoted glycosidations
Boons, G.J.P.H.,Delft, F. L. van,Klein, P. A. M. van der,Marel, G. A. van der,Boom, J. H. van
, p. 885 - 904 (2007/10/02)
The synthesis of methyl(ethyl) 2-thio-KDO (i.e. 1, 2, 5, 7 and 10) and ethyl 1-thio-LD-Hepp (i.e. 26 and 43) derivatives will be described.The latter derivatives proved to be suitable donors in iodonium ion (NIS/TfOH) promoted glycosidation reactions.The