473659-26-6Relevant articles and documents
An efficient and convenient synthesis of 4-vinylimidazoles using a novel Horner-Wadsworth-Emmons (HWE) reagent: Synthetic studies toward novel histamine H3-ligands
Harusawa, Shinya,Koyabu, Shuji,Inoue, Yasutoshi,Sakamoto, Yasuhiko,Araki, Lisa,Kurihara, Takushi
, p. 1072 - 1078 (2007/10/03)
A novel Horner-Wadsworth-Emmons (HWE)-type reagent 1 reacted readily with various aldehydes and ketones to produce (E)-vinylimidazoles 2 in good yields. The synthetic utility of 1 was demonstrated by the efficient preparation of four histamine H3 ligands 3 by simple hydrogenation of 2.