473733-30-1

Usage

Uses

Used in Pharmaceutical Industry:
(1R)-2,2-dimethyl-1-(5-methyl-2-furyl)propan-1-amine is used as a key intermediate in the synthesis of various pharmaceuticals due to its ability to serve as a chiral building block. This allows for the creation of enantiomerically pure compounds, which is crucial for ensuring the desired biological activity and minimizing potential side effects.
Used in Organic Synthesis:
In the field of organic synthesis, (1R)-2,2-dimethyl-1-(5-methyl-2-furyl)propan-1-amine is utilized as a versatile starting material for the development of new bioactive compounds. Its unique structure and functional groups enable the formation of a wide range of derivatives, expanding the scope of potential applications in medicinal chemistry and drug discovery.
Used in Asymmetric Synthesis:
(1R)-2,2-dimethyl-1-(5-methyl-2-furyl)propan-1-amine is employed in asymmetric synthesis processes to produce enantiomerically pure compounds. This is particularly important in the pharmaceutical industry, where the different enantiomers of a drug can have significantly different effects on the body. The ability to selectively produce the desired enantiomer can lead to more effective and safer medications.
Used in Drug Development:
Due to its unique structure and properties, (1R)-2,2-dimethyl-1-(5-methyl-2-furyl)propan-1-amine has potential applications in the development of new drugs and therapeutics. Its use in organic synthesis and asymmetric synthesis allows for the creation of novel compounds with potential biological activity, contributing to the advancement of medical treatments and therapies.

Upstream product

• 221375-53-7 (R_S,E)-N-(2,2---dimethylpropylidene)-2-methylpropane-2-sulfinamide 
• 630-19-3 pivalaldehyde 
• 620-02-0 5-Methylfurfural 

Downstream Products

• 681512-77-6 C₂₂H₂₆F₃N₅O₄S 
• 681513-52-0 C₂₁H₂₇N₅O₄S 

Relevant academic research and scientific papers

MODULATORS OF CHEMOKINE RECEPTORS

Compounds are provided as chemokine inhibitors having the structure: Formula (A).

AMINE-LINKED PYRIDYL AND PHENYL SUBSTITUTED PIPERAZINE-PIPERIDINES WITH CXCR3 ANTAGONIST ACTIVITY

The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having th

Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5-methylfuran-2-yl) propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): A potent, orally bioavailable CXCR2/CXCR1 receptor antagonist

Structure-activity studies on lead cyclobutenedione 3 led to the discovery of 4 (SCH 527123), a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist with excellent cell-based activity. Compound 4 displayed good oral bioavailability in rat and may be a potential therapeutic agent for the treatment of various inflammatory diseases.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.