473797-75-0Relevant academic research and scientific papers
Homochiral Metal-Organic Frameworks with Tunable Nanoscale Channel Array and Their Enantioseparation Performance against Chiral Diols
Zhuo, Chao,Wen, Yuehong,Hu, Shengmin,Sheng, Tianlu,Fu, Ruibiao,Xue, Zhenzhen,Zhang, Hao,Li, Haoran,Yuan, Jigang,Chen, Xi,Wu, Xintao
, p. 6275 - 6280 (2017)
Enantioseparation is an integral process in the pharmaceutical industry, considering the ever-increasing demand for chiral medicine products. As a new material, porous metal-organic frameworks (MOFs) have shown their potential application in this field because their structures are easy to adjust and control. Though chiral recognition between racemic substrates and frameworks has made preliminary progress, discussions of their size-matching effects are rare. Herein with the help of channel-tunable homochiral MOFs (HMOFs), diols of different sizes have been separated in good enantiomeric excess (ee%). In addition, the ee% reaches 67.4% for the first time for diols as large as 1,1,2-triphenyl-1,2-ethanediol, which turns out to be the most effective value so far.
Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors
Wallén, Erik A. A.,Christiaans, Johannes A. M.,Forsberg, Markus M.,Ven?l?inen, Jarkko I.,M?nnist?, Pekka T.,Gynther, Jukka
, p. 4581 - 4584 (2007/10/03)
New dicarboxylic acid bis(L-prolyl-pyrrolidine) amides were synthesized, and their inhibitory activity against prolyl oligopeptidase from pig brain was tested in vitro. As compared with earlier described prolyl oligopeptidase inhibitors, these new compounds have in common an L-prolyl-pyrrolidine moiety, but the typical lipophilic acyl end group is replaced by another L-prolyl-pyrrolidine moiety connected symmetrically with a short dicarboxylic acid linker. These compounds are a new type of peptidomimetic prolyl oligopeptidase inhibitor.
