473907-72-1

Basic information

• Product Name: 5'-(2''-carboxymethylaziridino)-5'-deoxy-2',3'-bis(O-triethylsilyl)adenosine
• Synonyms: 5'-(2''-carboxymethylaziridino)-5'-deoxy-2',3'-bis(O-triethylsilyl)adenosine
• CAS NO: 473907-72-1
• Molecular Weight: 654.957
• Mol File: 473907-72-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-(2''-carboxymethylaziridino)-5'-deoxy-2',3'-bis(O-triethylsilyl)adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-(2''-carboxymethylaziridino)-5'-deoxy-2',3'-bis(O-triethylsilyl)adenosine(473907-72-1)
• EPA Substance Registry System: 5'-(2''-carboxymethylaziridino)-5'-deoxy-2',3'-bis(O-triethylsilyl)adenosine(473907-72-1)

Safety Data

• Hazardous Substances Data: 473907-72-1(Hazardous Substances Data)

Upstream product

• 10288-11-6 Benzyl 2,3-dibromopropionate 
• 473907-69-6 5’-amino-5’-deoxy-2’,3’-bis(O-triethylsilyl)adenosine 
• 994-30-9 triethylsilyl chloride 
• 362-75-4 2',3'-isopropylidene adenosine 
• 473907-68-5 5'-azido-5'-deoxy-2',3'-bis(O-triethylsilyl)adenosine 
• 34245-48-2 5'-azido-5'-deoxy-2',3'-O-isopropylidene adenosine 
• 737-76-8 5'-azido-5'-deoxyadenosine 

Relevant articles and documents

Expeditious synthesis of aziridine-based cofactor mimics

S-Adenosyl-L-methionine mimics were synthesized in a linear fashion highlighting methodology that bypasses the need for adenine base protection. These aziridine-based cofactor mimics are envisioned as useful biochemical tools and potential therapeutic agents whose mechanism of action hinges upon aberrant methyltransferase enzymes. Aziridination of the 5′ position of adenosine was effected by convergence of suitably protected 5′-aminoadenosine with various dibromopropionates. The economy and high yields for this route to said aziridine-based cofactors is highly amenable to large-scale chemistry which no doubt will be vital to their development as therapeutics and biochemical tools.