10288-11-6

Basic information

• Product Name: BENZYL 2,3-DIBROMOPROPANOATE
• Synonyms: BENZYL 2,3-DIBROMOPROPANOATE
• CAS NO: 10288-11-6
• Molecular Formula: C₁₀H₁₀Br₂O₂
• Molecular Weight: 321.99
• Product Categories: pharmacetical
• Mol File: 10288-11-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 327.6°Cat760mmHg
• Flash Point: 152°C
• Appearance: /
• Density: 1.735g/cm³
• Vapor Pressure: 0.0002mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: BENZYL 2,3-DIBROMOPROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL 2,3-DIBROMOPROPANOATE(10288-11-6)
• EPA Substance Registry System: BENZYL 2,3-DIBROMOPROPANOATE(10288-11-6)

Safety Data

• Hazardous Substances Data: 10288-11-6(Hazardous Substances Data)

Usage

General Description

Benzyl 2,3-dibromopropanoate is a chemical compound with the molecular formula C11H11Br2O2. It is a colorless to light yellow liquid that is commonly used as a fragrance ingredient in perfumes and other personal care products. It is also used as a chemical intermediate in the synthesis of pharmaceuticals and other chemicals. Benzyl 2,3-dibromopropanoate is flammable and may cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. It is important to handle this chemical with care and follow proper safety precautions when working with it.

InChI:InChI=1/C10H10Br2O2/c11-6-9(12)10(13)14-7-8-4-2-1-3-5-8/h1-5,9H,6-7H2

Upstream product

• 2495-35-4 benzylacrylate 

Downstream Products

• 119407-74-8 1-(2-Hydroxy-1,1-dimethyl-ethyl)-aziridine-2-carboxylic acid benzyl ester 
• 328119-67-1 2-azidoacrylic acid benzyl ester 
• 473907-72-1 5'-(2''-carboxymethylaziridino)-5'-deoxy-2',3'-bis(O-triethylsilyl)adenosine 
• 328119-58-0 Benzyl 2H-azirine-3-carboxylate 
• 328119-60-4 Benzyl 2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)aziridine-2-carboxylate 

Relevant articles and documents

Dibrominated addition and substitution of alkenes catalyzed by Mn2(CO)10

A practical method for the dibromination of alkenes without using molecular bromine is consistently appealing in organic synthesis. Herein, we report Mn-catalyzed dibrominated addition and substitution of alkenes only with N-bromosuccinimide, producing a variety of synthetically valuable dibrominated compounds in moderate to high yields. This journal is

Organocatalysis as a safe practical method for the stereospecific dibromination of unsaturated compounds

Organocatalytic stereospecific dibromination of a wide variety of functionalized alkenes was achieved using a stable, inexpensive halogen source, 1,3-dibromo 5,5-dimethylhydantoin, and a simple thiourea catalyst at room temperature. The presence of a tertiary amine enhanced the rate of the dibromination reaction, and yields were good in various solvents, including aqueous solvents. The procedure was extended to alkynes and aromatic rings and to dichlorination reactions by using the 1,3-dichloro hydantoin derivative.

Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use

The present invention discloses compounds and methods used to specifically target substrates of methylation by S-adenosyl-L-methionine (SAM)-dependent methyltransferases. The substrates can be peptides, single stranded nucleic acids or double stranded nucleic acids, including RNA, DNA and PNA or phospholipids. The compounds disclosed are SAM analogs that are ligated to a methylation site by the methyltransferase. Also disclosed, are reacting groups that are ligatable to the cofactor analogs and can also be used as detectable labels. The reacting group can be used to cleave the substrate providing a methylation footprint. The invention can be used clinically to determine methylation state of a gene or gene promoter such as those involved in imprinting and transcription. In some preferred embodiments, the invention includes a kit, which can include one or more suitable SAM analogs and may include one or more detectable labels. In other preferred embodiments, the invention includes a pharmaceutical composition.