473934-57-5

Upstream product

• 2986-19-8 carbamimidothioic acid methyl ester 
• 90766-97-5 5-bromo-6-phenylpyridazin-3(2H)-one 
• 72857-86-4 α,β-dibromo-γ-phenylcrotonolactone 

Downstream Products

• 473934-58-6 5-methoxy-6-phenyl-3(2H)-pyridazinone 
• 442123-58-2 5-methylsulfonyl-6-phenyl-3(2H)-pyridazinone 

Relevant academic research and scientific papers

Pyridazines. Part XXIX: Synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions

A series of 6-phenyl-3(2H)-pyridazinones with a diverse range of substituents in the 5-position have been prepared and evaluated in the search for new antiplatelet agents. A significant dependence of the substituent on the inhibitory effect has been observed. The pharmacological study of these compounds confirms that modification of the chemical group at position 5 of the 6-phenyl-3(2H)-pyridazinone system influences both variations in the antiplatelet activity and the mechanism of action.