473987-22-3

Upstream product

• 141-75-3 butyryl chloride 
• 473987-20-1 benzyl 1-[[(3R,5S)-7-chloro-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-5-(2,3-dimethoxyphenyl)-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate 
• 189060-51-3 (3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid 
• 189059-61-8 ethyl (3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetate 
• 473987-05-2 ethyl (S)-3-[N-[4-chloro-2-(α-hydroxy-2,3-dimethoxybenzyl)phenyl]-N-(3-hydroxy-2,2-dimethylpropyl)carbamoyl]acrylate 
• 189059-71-0 N-[[(3R,5S)-1-(3-hydroxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetic acid 
• 189059-65-2 ethyl 1-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate 
• 189059-60-7 (S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol 
• 189059-58-3 (-)-2-amino-5-chloro-α-(2,3-dimethoxyphenyl)benzyl alcohol 
• 597-31-9 2,2-dimethyl-3-hydroxypropionaldehyde 

Relevant academic research and scientific papers

Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis

Modification of the carboxyl group at the 3-position and introduction of protective groups to the hydroxy group of the 4,1-benzoxazepine derivative 2 (metabolite of 1) were carried out, and the inhibitory activity for squalene synthase and cholesterol syn