474-75-9

Basic information

• Product Name: 3-fluorocholest-5-ene
• CAS NO: 474-75-9
• Molecular Formula: C₂₇H₄₅F
• Molecular Weight: 388.6446
• Mol File: 474-75-9.mol

Chemical Properties

• Boiling Point: 452.2°C at 760 mmHg
• Flash Point: 379.7°C
• Density: 0.97g/cm³
• Vapor Pressure: 6.14E-08mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 3-fluorocholest-5-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluorocholest-5-ene(474-75-9)
• EPA Substance Registry System: 3-fluorocholest-5-ene(474-75-9)

Safety Data

• Hazardous Substances Data: 474-75-9(Hazardous Substances Data)

Upstream product

• 465-54-3 3,5-cyclocholesterol 
• 465-54-3 3α,5α-cyclo-cholestan-6α-ol 
• 465-54-3 3α,5α-cyclo-cholestan-6β-ol 
• 53496-46-1 O-((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl) S-methyl carbonodithioate 
• 2469-23-0 dicholesteryl ether 
• 465-54-3 3α,5-cyclo-5α-cholestan-6β-ol 
• 57-88-5 cholesterol 
• 57-88-5 cholesterol 
• 2930-80-5 cholesteryl iodide 

Relevant articles and documents

Preparation method of fluoride and intermediate thereof (by machine translation)

The invention discloses a preparation method of fluoride and an intermediate thereof. The preparation method comprises the following steps: in the presence of a basic reagent, the compound III and the thionyl fluoride are reacted in an organic solvent to obtain the compound of the formula I. The preparation method can obtain the fluorosulfite compound in a high yield, and has good functional group compatibility and substrate universality. (by machine translation)

A Series of Deoxyfluorination Reagents Featuring OCF2Functional Groups

Research on perfluoroalkyl ether carboxylic acids (PFECAs) as alternatives for perfluoroalkyl substances continues with the goal of protecting the environment. However, very little is known about the utilization of decomposition products of PFECAs. We report herein a new series of deoxyfluorination reagents featuring OCF2 functional groups derived from certain PFECAs. Alkyl fluorides were generated from various alcohols in ≤97% yield by these novel reagents. The mechanistic experiment verified in situ generation of carbonic difluoride (COF2).

1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine: A new selective fluorinating agent

The title compound has been prepared in 96-98% yield by the reaction of tetrafluoroethylene and dimethylamine. 1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine (1) is found to be an effective reagent for the conversion of alcohols into alkyl fluorides. Reaction of 1 and primary alcohols proceeds with high yield formation of the corresponding alkyl fluorides at elevated temperature. However, the reaction of secondary and tertiary alcohols rapidly takes place at 0-10°C, producing corresponding alkyl fluorides as major product along with some olefins.

Observations on the Reaction of Xanthate Esters with 4-Methyl(difluoroiodo)benzene: a New Method for the Conversion of Alcohols to Alkyl Fluorides

Treatment of a range of S-methyldithiocarbonates (xanthates) with 4-methyl(difluoroiodo)benzene gives the corresponding alkyl fluorides.

SYNTHESIS OF 3β-FLUORO DERIVATIVES OF 7-DEHYDROCHOLESTEROL AND OF ERGOSTEROL

It has been established that the fluorination of 3β-hydroxy-Δ5,7-steroids, unlike that of 3β-hydroxy-Δ5-steroids, does not lead to the formation of 3β-fluoro derivatives.The reaction products are 3α,5α-cyclo-Δ6,8(14) compo