4740-46-9

Usage

Uses

Used in Pharmaceutical Research:
2-Hydrazino-2-oxo-N-phenylacetamide is used as a building block for the development of new drugs. Its unique structure and reactivity contribute to the creation of novel compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Hydrazino-2-oxo-N-phenylacetamide serves as a key intermediate for the synthesis of various organic compounds. Its reactivity allows for the formation of new chemical bonds and the creation of diverse molecular structures.
Used in Chemical Reactions:
2-Hydrazino-2-oxo-N-phenylacetamide is utilized in various chemical reactions, such as condensation, substitution, and rearrangement reactions. Its participation in these reactions enables the synthesis of a wide range of chemical products.
Used in Industrial Processes:
2-HYDRAZINO-2-OXO-N-PHENYLACETAMIDE may also find applications in industrial processes, where its unique properties can be harnessed for the production of specialty chemicals, materials, or other products.
Safety Considerations:
It is important to handle 2-Hydrazino-2-oxo-N-phenylacetamide with care, as it may have potential health and safety hazards associated with its use. Proper safety measures should be taken to minimize risks during its handling and application.

InChI:InChI=1/C8H9N3O2/c9-11-8(13)7(12)10-6-4-2-1-3-5-6/h1-5H,9H2,(H,10,12)(H,11,13)

Upstream product

• 13797-22-3 methyl N-phenyloxamate 
• 1457-85-8 Ethyl oxanilate 

Downstream Products

• 53117-36-5 phenyl-oxalamic acid isopropylidenehydrazide 
• 108098-02-8 2-Oxo-3-(phenylaminooxalyl-hydrazono)-2,3-dihydro-1H-indole-7-carboxylic acid 
• 1049804-87-6 2-(2-(ethylcarbamothioyl)hydrazinyl)-2-oxo-N-phenylacetamide 

Relevant academic research and scientific papers

Synthesis, spectroscopic characterization and thermal behavior of metal complexes formed with (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N- phenylacetamide (H2OI)

Complexes of Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and U(IV)O2 with (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide (H2OI) are reported and have been characterized by various spectroscopic techniques like (IR, UV-Vis, ESR 1H and 13C NMR) as well as magnetic and thermal (TG and DTA) measurements. It is found that the ligand behaves as a neutral tridentate, neutral tetradentate, monoanionic tridentate, monoanionic tridentate and dianionic tridentate. An octahedral geometry for all complexes except [Cu2(H2OI)(OAc) 4](H2O)2 and [Cu(HOI)Cl](H2O) 2 which have a square planar geometry. Furthermore, kinetic parameters were determined for each thermal degradation stage of some studied complexes using Coats-Redfern and Horowitz-Metzger methods. The bond lengths, bond angles, HOMO, LUMO and dipole moments have been calculated to confirm the geometry of the ligand and the investigated complexes.

First row transition metal complexes of (E)-2-(2-(2-hydroxybenzylidene) hydrazinyl)-2-oxo-N-phenylacetamide complexes

Manganese(II), iron(II), cobalt(II), nickel(II), copper(II), and chromium(III) complexes of (E)-2-(2-(2-hydroxybenzylidene)hydrazinyl)-2-oxo-N- phenylacetamide were synthesized and characterized by elemental and thermal (TG and DTA) analyses, IR, UV-vis and 1H NMR spectra as well as magnetic moment. Mononuclear complexes are obtained with 1:1 molar ratio except [Mn(HOS)2(H2O)2] and [Co(OS) 2](H2O)2 complexes which are obtained with 1:2 molar ratios. The IR spectra of ligand and metal complexes reveal various modes of chelation. The ligand behaves as a monobasic bidentate one and coordination occurs via the enolic oxygen atom and azomethine nitrogen atom. The ligand behaves also as a monobasic tridentate one and coordination occurs through the carbonyl oxygen atom, azomethine nitrogen atom and the hydroxyl oxygen. Moreover, the ligand behaves as a dibasic tridentate and coordination occurs via the enolic oxygen, azomethine nitrogen and the hydroxyl oxygen atoms. The electronic spectra and magnetic moment measurements reveal that all complexes possess octahedral geometry except the copper complexes possesses a square planar geometry. From the modeling studies, the bond length, bond angle, HOMO, LUMO and dipole moment had been calculated to confirm the geometry of the ligands and their investigated complexes. The thermal studies showed the type of water molecules involved in metal complexes as well as the thermal decomposition of some metal complexes. The protonation constant of the ligand and the stability constant of metal complexes were determined pH-metrically in 50% (v/v) dioxane-water mixture at 298 K and found to be consistent with Irving-Williams order. Moreover, the minimal inhibitory concentration (MIC) of these compounds against Staphylococcus aureus, Escherechia coli and Candida albicans were determined.