474012-78-7Relevant academic research and scientific papers
6-Methoxy-indanone derivatives as potential probes for β-amyloid plaques in Alzheimer's disease
Nan, Dou-Dou,Gan, Chang-Sheng,Wang, Chen-Wei,Qiao, Jin-Ping,Wang, Xin-Meng,Zhou, Jiang-Ning
, p. 117 - 128 (2016)
A series of 6-methoxy indanone derivatives was synthesized and evaluated as potential probes for β-amyloid plaque imaging in Alzheimer's disease (AD). Two derivatives (5d and 5k) displayed significant binding abilities in fluorescent staining experiments
NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID
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Page/Page column 17-18, (2009/02/10)
The present invention provides a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagencity. Provided is a compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represents a carbon or nitrogen; R1 is a halogen substituent; R2 is a halogen substituent; and m is an integer of 0 to 2, provided that at least one of R1 and R2 is a radioactive halogen substituent, at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4 as well as a low-toxic diagnostic agent comprising a compound represented by the preceding formula or a salt thereof.
NOVEL COMPOUND HAVING AFFINITY TO AMYLOID
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Page/Page column 16, (2009/03/07)
The invention relates to a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagenicity, and also relates to a low-toxic diagnostic agent for Alzheimer's disease containing the compound. The compound is represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represent a carbon or a nitrogen, and R3 is a group represented by the following formula: wherein R1 is a radioactive halogen substituent; m is an integer of 0 to 4; and n is an integer of 0 or 1, provided that at least one of A1, A2, A3 and A4 represents a carbon, and R3 binds to a carbon represented by A1, A2, A3 or A4.
Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting β-amyloid plaques in the brain
Zhuang, Zhi-Ping,Kung, Mei-Ping,Wilson, Alan,Lee, Chi-Wan,Pl?ssl, Karl,Hou, Catherine,Holtzman, David M.,Kung, Hank F.
, p. 237 - 243 (2007/10/03)
A series of novel β-amyloid (Aβ) aggregate-specific ligands, 2-(4′-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine, 16(IMPY), and its related derivatives were prepared. An in vitro binding study with preformed Aβ aggregates showed that 16(IMPY) and its
